Uniparental inheritance

Uniparental inheritance

Uniparental inheritance is a non-mendelian form of inheritance that consists of the transmission of genotypes from one parental type to all progeny. That is, all the genes in offspring will originate from only the mother or only the father. This phenomenon is most commonly observed in eukaryotic

  1. ^ a b http://article.pubs.nrc-cnrc.gc.ca/RPAS/rpv?hm=HInit&afpf=g05-082.pdf&journal=gen&volume=48
  2. ^ http://www.pnas.org/content/92/25/11331.full.pdf
  3. ^ Sutovsky, P., et al. (1999). "Ubiquitin tag for sperm mitochondria".   Discussed in Science News.


See also

Like all other genetic concepts, the discovery of uniparental inheritance stems from the days of an Augustinian priest known as Gregor Johann Mendel. The soon-to-be "father of modern genetics" spent his days conducting hybridization experiments on pea plants(Pisum sativum) in his monastery's garden. During a period of seven years (1856 to 1863), Mendel cultivated and tested some 29,000 pea plants which lead to him deducing the two famous generalizations known as Mendel's Laws of Heredity. The first, the law of segregation, states that "when any individual produces gametes, the copies of a gene separate, so that each gamete receives only one copy". The second, the law of independent assortment, states that "alleles of different genes assort independently of one another during gamete formation". Although his work was published, it lay dormant until it was rediscovered in 1900 by Hugo de Vries and Carl Correns but it was not until 1909 that non-mendelian inheritance was even suggested. Carl Erich Correns and Erwin Baur, in separately conducted researches on Pelargonium and Mirabilis plants, observed a green-white variation (later found as the result of mutations in the chloroplast genome) that did not follow the Mendelian laws of inheritance. Nearly twenty years later, non-mendelian inheritance of a mitochondrial mutation was also observed and, in the sixties, it was proven that that chloroplasts and mitochondria have their own DNA and that they are capable translation, transcription, and replication independent of the nucleus. Soon after, the discoveries of uniparental and doubly uniparental inheritance came.[1]


Although most of the eukaryotic sub-cellular parts do not have their own maternal inheritance is almost the exclusive form of inheritance. Although, during egg cell fertilization, mitochondria are brought into the fertilized cell both by the egg cell and the sperm, the paternal mitochondria are usually marked with ubiquitin and are later destroyed.[3] Even if they are not destroyed, the DNA's of different mitochondria rarely genetically recombine with one another. Thus, mitochondria in most animals are inherited from the maternal type only.




  • Examples 1
    • Organelles 1.1
  • History 2
  • See also 3
  • References 4