U-46619

U46619
Identifiers
CAS number 56985-40-1
PubChem 5311493
IUPHAR ligand 1888
Jmol-3D images Image 1
Properties
Molecular formula C21H34O4
Molar mass 350.49 g/mol
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

U46619 is a stable synthetic analog of the endoperoxide prostaglandin PGH2 first prepared in 1975,[1] and acts as a thromboxane A2 (TP) receptor agonist.[2] It potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations.[3] and exhibits many properties similar to thromboxane A2, including shape change and aggregation of platelets [4] and smooth muscle contraction. U46619 is a vasoconstrictor that mimics the hydroosmotic effect of vasopressin.[5]

References