ATP synthase F0 subunit 8
Symbols  ; ATPase8; MTATP8
External IDs GeneCards:
Species Human Mouse
Entrez n/a
Ensembl n/a
UniProt n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a
PubMed search n/a
ATP synthase protein 8 (metazoa)
Symbol ATP-synt_8
Pfam PF00895
Pfam clan CL0255
InterPro IPR001421
Plant ATP synthase F0 subunit 8
Symbol YMF19
Pfam PF02326
Pfam clan CL0255
InterPro IPR003319
Fungal ATP synthase protein 8 (A6L)
Symbol Fun_ATP-synt_8
Pfam PF05933
Pfam clan CL0255
InterPro IPR009230

ATP synthase protein 8 is an protein that in humans is encoded by the MT-ATP8 gene. It is a subunit of mitochondrial ATP synthase.

This subunit appears to be an integral component of the stator stalk in yeast mitochondrial F-ATPases.[1] The stator stalk is anchored in the membrane, and acts to prevent futile rotation of the ATPase subunits relative to the rotor during coupled ATP synthesis/hydrolysis. This subunit may have an analogous function in Metazoa. Subunit 8 differs in sequence between Metazoa, plants and fungi).


  1. ^ Stephens AN, Khan MA, Roucou X, Nagley P, Devenish RJ (May 2003). "The molecular neighborhood of subunit 8 of yeast mitochondrial F1F0-ATP synthase probed by cysteine scanning mutagenesis and chemical modification". J. Biol. Chem. 278 (20): 17867–75. PMID 12626501. doi:10.1074/jbc.M300967200. 

Further reading

  • Torroni A, Achilli A, Macaulay V, et al. (2006). "Harvesting the fruit of the human mtDNA tree.". Trends Genet. 22 (6): 339–45. PMID 16678300. doi:10.1016/j.tig.2006.04.001. 
  • Bodenteich A, Mitchell LG, Polymeropoulos MH, Merril CR (1993). "Dinucleotide repeat in the human mitochondrial D-loop.". Hum. Mol. Genet. 1 (2): 140. PMID 1301157. doi:10.1093/hmg/1.2.140-a. 
  • Lu X, Walker T, MacManus JP, Seligy VL (1992). "Differentiation of HT-29 human colonic adenocarcinoma cells correlates with increased expression of mitochondrial RNA: effects of trehalose on cell growth and maturation.". Cancer Res. 52 (13): 3718–25. PMID 1377597. 
  • Marzuki S, Noer AS, Lertrit P, et al. (1992). "Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.". Hum. Genet. 88 (2): 139–45. PMID 1757091. doi:10.1007/bf00206061. 
  • Moraes CT, Andreetta F, Bonilla E, et al. (1991). "Replication-competent human mitochondrial DNA lacking the heavy-strand promoter region.". Mol. Cell. Biol. 11 (3): 1631–7. PMC 369459. PMID 1996112. 
  • Attardi G, Chomyn A, Doolittle RF, et al. (1987). "Seven unidentified reading frames of human mitochondrial DNA encode subunits of the respiratory chain NADH dehydrogenase.". Cold Spring Harb. Symp. Quant. Biol. 51 (1): 103–14. PMID 3472707. doi:10.1101/sqb.1986.051.01.013. 
  • Chomyn A, Cleeter MW, Ragan CI, et al. (1986). "URF6, last unidentified reading frame of human mtDNA, codes for an NADH dehydrogenase subunit.". Science 234 (4776): 614–8. PMID 3764430. doi:10.1126/science.3764430. 
  • Chomyn A, Mariottini P, Cleeter MW, et al. (1985). "Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.". Nature 314 (6012): 592–7. PMID 3921850. doi:10.1038/314592a0. 
  • Anderson S, Bankier AT, Barrell BG, et al. (1981). "Sequence and organization of the human mitochondrial genome.". Nature 290 (5806): 457–65. PMID 7219534. doi:10.1038/290457a0. 
  • Montoya J, Ojala D, Attardi G (1981). "Distinctive features of the 5'-terminal sequences of the human mitochondrial mRNAs.". Nature 290 (5806): 465–70. PMID 7219535. doi:10.1038/290465a0. 
  • Horai S, Hayasaka K, Kondo R, et al. (1995). "Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.". Proc. Natl. Acad. Sci. U.S.A. 92 (2): 532–6. PMC 42775. PMID 7530363. doi:10.1073/pnas.92.2.532. 
  • Rieder MJ, Taylor SL, Tobe VO, Nickerson DA (1998). "Automating the identification of DNA variations using quality-based fluorescence re-sequencing: analysis of the human mitochondrial genome.". Nucleic Acids Res. 26 (4): 967–73. PMC 147367. PMID 9461455. doi:10.1093/nar/26.4.967. 
  • Andrews RM, Kubacka I, Chinnery PF, et al. (1999). "Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA.". Nat. Genet. 23 (2): 147. PMID 10508508. doi:10.1038/13779. 
  • Ingman M, Kaessmann H, Pääbo S, Gyllensten U (2001). "Mitochondrial genome variation and the origin of modern humans.". Nature 408 (6813): 708–13. PMID 11130070. doi:10.1038/35047064. 
  • Finnilä S, Lehtonen MS, Majamaa K (2001). "Phylogenetic network for European mtDNA.". Am. J. Hum. Genet. 68 (6): 1475–84. PMC 1226134. PMID 11349229. doi:10.1086/320591. 
  • Maca-Meyer N, González AM, Larruga JM, et al. (2003). "Major genomic mitochondrial lineages delineate early human expansions.". BMC Genet. 2: 13. PMC 55343. PMID 11553319. doi:10.1186/1471-2156-2-13. 
  • Herrnstadt C, Elson JL, Fahy E, et al. (2002). "Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups.". Am. J. Hum. Genet. 70 (5): 1152–71. PMC 447592. PMID 11938495. doi:10.1086/339933. 
  • Silva WA, Bonatto SL, Holanda AJ, et al. (2002). "Mitochondrial genome diversity of Native Americans supports a single early entry of founder populations into America.". Am. J. Hum. Genet. 71 (1): 187–92. PMC 384978. PMID 12022039. doi:10.1086/341358. 
  • Mishmar D, Ruiz-Pesini E, Golik P, et al. (2003). "Natural selection shaped regional mtDNA variation in humans.". Proc. Natl. Acad. Sci. U.S.A. 100 (1): 171–6. PMC 140917. PMID 12509511. doi:10.1073/pnas.0136972100. 
  • Ingman M, Gyllensten U (2003). "Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines.". Genome Res. 13 (7): 1600–6. PMC 403733. PMID 12840039. doi:10.1101/gr.686603. 

This article incorporates text from the public domain Pfam and InterPro IPR001421