Inactivated vaccine

Inactivated vaccine

An inactivated vaccine (or killed vaccine) consists of virus particles which are grown in culture and then killed using a method such as heat or formaldehyde.

Examples

Types include:

Inactivated vaccines are contrasted with attenuated vaccines, or "live" vaccines. Examples of "live" (i.e. attenuated) vaccines include:

Mechanism

The virus particles are destroyed and cannot replicate, but the virus capsid proteins are intact enough to be recognized by the immune system and evoke a response. When manufactured correctly, the vaccine is not infectious, but improper inactivation can result in intact and infectious particles. Because the properly produced vaccine does not reproduce, booster shots are required periodically to reinforce the immune response.

References