U12 snRNA

U12 snRNA

U12 minor spliceosomal RNA
Predicted secondary structure and sequence conservation of U12
Symbol U12
Rfam RF00007
Other data
RNA type Gene; snRNA; splicing
Domain(s) Eukaryota
GO 0005693
SO Template:SO

U12 minor spliceosomal RNA is formed from U12 small nuclear (snRNA), together with U4atac/U6atac, U5, and U11 snRNAs and associated proteins, forms a spliceosome that cleaves a divergent class of low-abundance pre-mRNA introns. Although the U12 sequence is very divergent from that of U2, the two are functionally analogous.[1] The predicted secondary structure of U12 RNA is published,[2] but the alternative single hairpin in the 3' end shown here seems to better match the alignment of divergent Drosophila melanogaster and Arabidopsis thaliana sequences.[3] The sequences U12 introns that are spliced out are collected in a biological database called the U12 intron database.


External links

  • Rfam