Typhoid vaccine

Typhoid vaccine

Typhoid vaccine
Vaccine description
Target disease Typhoid
Clinical data
AHFS/Drugs.com
MedlinePlus
Legal status
?
Identifiers
CAS number  YesY
ATC code J07 J07 J07
 N   

Typhoid vaccines are vaccines developed to prevent typhoid fever.

There are two effective types:[1]

Ty21a is licensed for use from age six years and older. Boosters are recommended every 5 years.[2] The Vi capsular polysaccharide vaccine is licensed for use from age two years and older, and boosters are required every three years.[3]

Almroth Edward Wright developed an effective inactivated whole-cell typhoid vaccine that was introduced in 1896.[1] Due to side-effects its usage was eventually discontinued.[3]

An experimental vaccine called Vi-rEPA has showed promising results in trials so far, indicating higher effectiveness and longer immunity. However, it has yet to be licensed for use.[1] It is on the health system.[4]

Available preparations

  • Vi polysaccharide vaccine: Typhim Vi® (Sanofi Pasteur); Typherix® (GSK)[3]
  • Combined hepatitis A/Vi polysaccharide vaccine: ViATIM® (Sanofi Pasteur); Hepatyrix® (GSK)[3]
  • Ty21a oral vaccine: Vivotif® (Crucell)[3]

References

  1. ^ a b c Fraser A, Goldberg E, Acosta CJ, Paul M, Leibovici L (2007). "Vaccines for preventing typhoid fever". Cochrane Database Syst Rev (3): CD001261.  
  2. ^ http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142807.pdf
  3. ^ a b c d e Salisbury, D; Ramsay, M; Noakes, K. ""Chapter 33: Typhoid"". Immunisation against infectious disease. Department of Health. p. 418.  
  4. ^ "WHO Model List of EssentialMedicines". World Health Organization. October 2013. Retrieved 22 April 2014.