Trypanosomiasis vaccine

Trypanosomiasis vaccine

A Trypanosomiasis vaccine is a vaccine against trypanosomiasis. No effective vaccine currently exists, but development of a vaccine is the subject of current research. The Bill & Melinda Gates Foundation has been involved in funding research.[1]

There are many obstacles to development of such a vaccine. One obstacle is variant surface glycoprotein which makes it difficult for the immune system to recognize the infectious organism.[2]

Also, Trypanosoma brucei has a direct inhibitory effect upon B cells.[3]

One strategy may involve a vaccine against the initial antigens.[4]

It has been suggested that it may be more productive to generate an immune response against the cysteine protease (for example, cruzipain), rather than the organism itself.[5][6]

There are two known subspecies that infect humans, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense.

See also