Total synthesis

Total synthesis

Total synthesis is the complete chemical reagents. [5]


  • History 1
    • Scope 1.1
  • References 2
  • External links 3


The discovery by Friedrich

  • The Organic Synthesis Archive
  • Total Synthesis Highlights
  • Total Synthesis News
  • Total syntheses schemes with reaction and reagent indices
  • Group Meeting Problems in Organic Chemistry

External links

  1. ^ Subject Areas
  2. ^ a b c d e  
  3. ^ Nicolaou, K. C. & Sorensen, E. J. 1996, Classics in Total Synthesis: Targets, Strategies, Methods, New York:John Wiley & Sons, ISBN 978-3-527-29231-8
  4. ^ Nicolaou, K. C. & Snyder, S. A., 2003, Classics in Total Synthesis II: More Targets, Strategies, Methods, New York:John Wiley & Sons, ISBN 978-3-527-30684-8
  5. ^ Discovery of Novel Synthetic Methodologies and Reagents during Natural Product Synthesis in the Post-Palytoxin Era Ahlam M. Armaly , Yvonne C. DePorre , Emilia J. Groso , Paul S. Riehl , and Corinna S. Schindler Chem. Rev., Article ASAP doi:10.1021/acs.chemrev.5b00034


A classic in total synthesis is cholesterol, cortisone, strychnine, lysergic acid, reserpine, chlorophyll, colchicine, vitamin B12 and prostaglandin F-2a. [2] Another gifted chemist is Elias James Corey who won the Nobel Prize in Chemistry in 1990 for lifetime achievement in total synthesis and the development of retrosynthetic analysis.


The difficulties posed by the total synthesis of a complex compound often lead to the development of new chemical reactions and routes that entail novel mechanisms, catalysts, or techniques. Finally since a total synthesis project will often span a variety of reactions, it serves to prepare chemists for pursuits in process chemistry, where encyclopedic knowledge of chemical reactions and a strong and accurate sense of chemical intuition are necessary.

Haller and Blanc synthesized camphor from camphoric acid. [2] Camphoric acid, however, had an unknown structure. In 1904, Finnish chemist Gustav Komppa became the first to succeed in manufacturing synthetic camphoric acid from diethyl oxalate and 3,3-dimethylpentanoic acid. The use of these precursors provided a demonstration for the structure of camphor, which is a complicated ring. William Perkin published another synthesis a short time later. At the time camphor was a scarce and expensive natural product with a worldwide demand. Komppa realized this and began industrial production of camphor in Tainionkoski, Finland, in 1907.

AgNCO + NH4Cl → (NH2)2CO + AgCl

He obtained urea artificially by treating silver cyanate with ammonium chloride. This was a rather simple synthesis.