Tomas Robert Lindahl
28 January 1938 
|Thesis||On the structure and stability of nucleic acids in solution (1967)|
|Known for||Clarification of cellular resistance to carcinogens|
Following his PhD, Lindahl did postdoctoral research at Princeton University and Rockefeller University. After moving to the United Kingdom he joined the Imperial Cancer Research Fund (now Cancer Research UK) as a researcher in 1981.
Awards and honoursLindahl won the Royal Medal for "making fundamental contributions to our understanding of DNA repair. His achievements stand out for their great originality, breadth and lasting influence." He is a member of the Norwegian Academy of Science and Letters. He was awarded the Royal Society's Royal Medal in 2007 and the Copley Medal in 2010. He was elected a founding Fellow of the Academy of Medical Sciences in 1998. His nomination for the Royal Society reads
|“||Dr. Tomas Lindahl is noted for his contributions to the comprehension of DNA repair at the molecular level in bacterial and mammalian cells. He was the first to isolfiate a mammalian DNA ligase and to describe a totally unanticipated novel group of DNA glycosylases as mediators of DNA excision repair. He has also discovered a unique class of enzymes in mammalian cells, namely the methyltransferases, which mediate the adaptive response to alkylation of DNA and has shown that the expression of these enzymes is regulated by the ada gene. More recently he has elucidated the molecular defect in Blooms syndrome to be the lack of DNA ligase I. Apart from providing profound insights into the nature of the DNA repair process his very important contributions promise to facilitate the design of more selective chemotherapeutic drugs for the treatment of cancer. Lindahl has also made a number of significant contributions to understanding at the DNA level the mechanism of transformation of B-lymphocytes by the Epstein-Barr virus. The most notable of these was the first description of the occurrence in lymphoid cells of closed circular duplex viral DNA.||”|
- "LINDAHL, Tomas Robert". Who's Who 2014. (subscription required)
- "Lindahl, Tomas Robert: EC/1988/20". London: The Royal Society. Archived from the original on 2014-11-21.
- Gerken, T.; Girard, C. A.; Tung, Y. -C. L.; Webby, C. J.; Saudek, V.; Hewitson, K. S.; Yeo, G. S. H.; McDonough, M. A.; Cunliffe, S.; McNeill, L. A.; Galvanovskis, J.;
- Tomas Lindahl from the Scopus bibliographic database.
- Lindahl, T. (1993). "Instability and decay of the primary structure of DNA". Nature 362 (6422): 709.
- Wood, R. D. (2001). "Human DNA Repair Genes". Science 291 (5507): 1284.
- Satoh, M. S.; Lindahl, T. (1992). "Role of poly(ADP-ribose) formation in DNA repair". Nature 356 (6367): 356.
- Trewick, S. C.; Henshaw, T. F.; Hausinger, R. P.; Lindahl, T; Sedgwick, B (2002). "Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage". Nature 419 (6903): 174–8.
- Barnes, D. E.; Lindahl, T (2004). "Repair and genetic consequences of endogenous DNA base damage in mammalian cells". Annual Review of Genetics 38: 445–76.
- Yang, Y. G.; Lindahl, T; Barnes, D. E. (2007). "Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease". Cell 131 (5): 873–86.
- Crow, Y. J.; Hayward, B. E.; Parmar, R; Robins, P; Leitch, A; Ali, M; Black, D. N.; Van Bokhoven, H; Brunner, H. G.; Hamel, B. C.; Corry, P. C.; Cowan, F. M.; Frints, S. G.; Klepper, J; Livingston, J. H.; Lynch, S. A.; Massey, R. F.; Meritet, J. F.; Michaud, J. L.; Ponsot, G; Voit, T; Lebon, P; Bonthron, D. T.; Jackson, A. P.; Barnes, D. E.; Lindahl, T (2006). "Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus". Nature Genetics 38 (8): 917–20.
- Lindahl, Tomas (1967). On the structure and stability of nucleic acids in solution. Stockholm.
- "Cancer Research UK Grants & Research - Tomas Lindahl". Retrieved 2008-11-10.
- "Royal recent winners". Retrieved 2008-11-10.
- "Gruppe 6: Cellebiologi og molekylærbiologi" (in Norwegian).