Tipepidine

Tipepidine

Tipepidine
Systematic (IUPAC) name
3-(di-2-thienylmethylene)-1-methylpiperidine
Clinical data
AHFS/Drugs.com
Legal status
Routes Oral
Identifiers
CAS number  Y
ATC code R05
PubChem
ChemSpider  Y
UNII  Y
KEGG  Y
Chemical data
Formula C15H17NS2 
Mol. mass 275.434 g/mol
 Y   

Tipepidine was discovered in the 1950s.[1] Under the trade-names (Bithiodine, Sotal, Antupex, Asverin) is used as a centrally-acting cough suppressant of the opioid type. It is a member of the thiambutene series of open-chain (methadone-related) synthetic opioids, which include Ohton (dimethylthiambutene), a strong narcotic analgesic used particularly in veterinary medicine in Japan and other East Asian countries. It was developed in Japan in 1959 and is used as the citrate and hibenzate salts. The usual dose is 20 mg every 4–6 hours. Its relative weakness and other properties make it a drug which is not controlled in most countries or internationally.

References

  1. ^ ES Patent 272195