Sodium salicylate

Sodium salicylate

Sodium salicylate
Identifiers
CAS number  YesY
PubChem
ChemSpider  YesY
UNII  YesY
EC number
DrugBank
KEGG  N
ChEMBL  YesY
RTECS number VO5075000
ATC code N02
Jmol-3D images Image 1
Properties
Molecular formula C7H5NaO3
Molar mass 160.10 g mol−1
Appearance white crystals
Melting point 200 °C (392 °F; 473 K)
Solubility in water 25.08 g/100 mL (-1.5 °C)
107.9 g/100 mL (15 °C)
124.6 g/100 mL (25 °C)
141.8 g/100 mL (78.5 °C)
179 g/100 g (114 °C)[1]
Solubility soluble in glycerol, 1,4-Dioxane, alcohol[1]
Solubility in methanol 26.28 g/100 g (15 °C)
34.73 g/100 g (67.2 °C)[1]
Hazards
GHS pictograms The exclamation-mark pictogram in the Globally Harmonized System of Classification and Labelling of Chemicals (GHS)[2]
GHS signal word Warning
GHS hazard statements H314, H331, H400[2]
GHS precautionary statements P210, P261, P273, P280, P305+351+338, P310[2]
EU classification Harmful Xn
R-phrases R22, R36/37/38
S-phrases S24/25, S26, S36/37/39
Main hazards Harmful
Eye hazard Irritant
NFPA 704
1
1
0
Autoignition temperature 250 °C (482 °F; 523 K)
LD50 930 mg/kg (rats, oral)[3]
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N   YesY/N?)

Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized from methyl salicylate (found in wintergreen plants or the bark of sweet birch tree) by reacting it with an excess of sodium hydroxide and heating it under reflux.[4]

Contents

  • Properties 1
  • Uses 2
  • References 3
  • External links 4

Properties

Sodium salicylate is of the salicylate family and this compound is known to trigger Reye's Syndrome in children and adults, usually following a viral infection such as influenza or chicken pox. Products containing such salicylates should not be given to children under the age of 19.

Uses

It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells [5][6][7] and also necrosis.[8] It is also a potential replacement for aspirin for people sensitive to it. It may also be used as a phosphor for the detection of vacuum ultraviolet radiation and electrons.[9]

References

  1. ^ a b c http://chemister.ru/Database/properties-en.php?dbid=1&id=2993
  2. ^ a b c Sigma-Aldrich Co., Sodium salicylate. Retrieved on 2014-05-26.
  3. ^ http://chem.sis.nlm.nih.gov/chemidplus/rn/54-21-7
  4. ^ Lehman, J.W., Operational Organich Chemistry, 4th ed., New Jersey, Prentice Hall, 2009
  5. ^ Klampfer, Lidija; Jörg Cammenga, Hans-Georg Wisniewski, Stephen D. Nimer (1999-04-01). "Sodium Salicylate Activates Caspases and Induces Apoptosis of Myeloid Leukemia Cell Lines". Blood 93 (7): 2386–94.  
  6. ^ Rae, Colin; Susana Langa; Steven J. Tucker; David J. MacEwan (2007-07-31). "Elevated NF-κB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis". Proceedings of the National Academy of Sciences of the USA 104 (31): 12790–5.  
  7. ^ Stark, Lesley A.; et al (May 2007). "Aspirin activates the NF-κB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer". Carcinogenesis 28 (5): 968–76.  
  8. ^ Schwenger, Paul; Edward Y. Skolnik; Jan Vilcek (1996-04-05). "Inhibition of Tumor Necrosis Factor-induced p42/p44 Mitogen-Activated Protein Kinase Activation by Sodium Salicylate". The Journal of Biological Chemistry 271 (14): 8089–94.  
  9. ^ Samson, James. "Vacuum Ultraviolet Spectroscopy". Pied Publications. Retrieved July 26, 2012. 

External links

  • Chemicalland21
  • Some synonyms
  • Safety data for sodium salicylate at Oxford University
  • Sodium salicylate, definitions at National Cancer Institute