Prostaglandin F receptor

Prostaglandin F receptor (FP)
Identifiers
PTGFR Gene
RNA expression pattern

Prostaglandin F receptor (FP) is a receptor for Prostaglandin F. It is encoded by the gene PTGFR.[1]

It is a member of the G-protein coupled receptor family.

Two transcript variants encoding different isoforms have been found for this gene.[1]

Functions

Main effects of prostaglandin binding to the receptor are:

Via activation of this receptor, PGF2-alpha mediates luteolysis,[1] and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus and gastrointestinal tract sphincters.[3]

Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor in ovarian luteal cells initiates luteolysis and thus induces parturition.[4]

See also

References

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.