Prostacyclin receptor

Prostaglandin I2 (prostacyclin) receptor (IP)
Identifiers
PTGIR Gene
RNA expression pattern

Prostacyclin receptor ( or prostaglandin I2 receptor, IP1) is a receptor for prostacyclin.

It is a member of the G-protein coupled receptor family. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor.[1]

Transduction

When binding a prostacyclin-molecule, the receptor changes conformation and activates Gs, with its activation of cAMP and increase in protein kinase A (PKA) activity.

In vasodilation

In vasodilation, the PKA activity causes phosphorylation of MLCK, decreasing its activity, resulting in dephosphorylation of MLC of myosin. The smooth muscle relaxation leads to vasodilation.[2]

Gene

The receptor is encoded by the human gene PTGIR.[1]


See also

References

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.