Probiotic

Probiotic

Élie Metchnikoff first suggested the possibility of colonizing the gut with beneficial flora in the early 20th century.

Probiotics are

  • Francisco Guarner, Gabriela Perdigon, Ge ́rard Corthier, Seppo Salminen, Berthold Koletzko & Lorenzo Morelli, 2005, "Should yoghurt cultures be considered probiotic?," British Journal of Nutrition 93:783–786, DOI 10.1079/BJN20051428, see [8], accessed 11 June 2015.

Further reading

  1. ^ a b c d e Rijkers GT, de Vos WM, Brummer RJ, Morelli L, Corthier G, Marteau P; De Vos; Brummer; Morelli; Corthier; Marteau (2011). "Health benefits and health claims of probiotics: Bridging science and marketing". British Journal of Nutrition 106 (9): 1291–6.  
  2. ^ a b Magdalena Araya, Catherine Stanton, Lorenzo Morelli, Gregor Reid, Maya Pineiro, et al., 2006, "Probiotics in food: health and nutritional properties and guidelines for evaluation," Combined Report of a Joint FAO/WHO Expert Consultation on Evaluation of Health and Nutritional Properties of Probiotics in Food Including Powder Milk with Live Lactic Acid Bacteria, Cordoba, Arentina, 1–4 October 2001, and Report of a Joint FAO/WHO Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food, London, Ontario, Canada, 30 April–1 May 2002 [FAO Food and Nutrition paper 85], pp. 1–50, Rome, Italy:World Health Organization (WHO), Food and Agricultural Organization (FAO) [of the United Nations], ISBN 9251055130, see [5], accessed 11 June 2015.
  3. ^ a b Élie [Ilya Ilyich] Metchnikoff, 2004 [1907], The prolongation of life: Optimistic studies, Springer Classics in Longevity and Aging, New York, NY:Springer, ISBN 0826118771, reprint of 1908 English edition by É.M., same title (P. Chalmers Mitchell, Ed.), New York, NY:Putnam, ISBN 0826118763, itself a translation of 1907 French edition by I.I.M., Essais optimistes, Paris:Heinemann, see [6], accessed 11 June 2015.
  4. ^ Starling S (10 November 2011). "EFSA calls for characterisation work as probiotic resubmissions loom". nutraingredients.com. William Reed Business Media. Retrieved 6 January 2015. 
  5. ^ a b Slashinski MJ, McCurdy SA, Achenbaum LS, Whitney SN, McGuire AL; McCurdy; Achenbaum; Whitney; McGuire (2012). Snake-oil," "quack medicine," and "industrially cultured organisms:" biovalue and the commercialization of human microbiome research""". BMC Medical Ethics 13: 28.  
  6. ^ Fuller, R., ed. (1992) Probiotics. The Scieniific Basis. Chapman & Hall, London, U.K
  7. ^ Alvarez-Olmos MI, Oberhelman RA; Oberhelman (2001). "Probiotic agents and infectious diseases: a modern perspective on a traditional therapy". Clin. Infect. Dis. 32 (11): 1567–76.  
  8. ^ Hamilton-Miller JM, Gibson GR, Bruck W; Gibson; Bruck (October 2003). "'"Some insights into the derivation and early uses of the word 'probiotic (PDF). Br. J. Nutr. 90 (4): 845.  
  9. ^ Schlundt, Jorgen. "Health and Nutritional Properties of Probiotics in Food including Powder Milk with Live Lactic Acid Bacteria" (PDF). Report of a Joint  
  10. ^ a b c Rijkers GT, Bengmark S, Enck P, Haller D, Herz U, Kalliomaki M, Kudo S, Lenoir-Wijnkoop I, Mercenier A, Myllyluoma E, Rabot S, Rafter J, Szajewska H, Watzl B, Wells J, Wolvers D, Antoine JM; Bengmark; Enck; Haller; Herz; Kalliomaki; Kudo; Lenoir-Wijnkoop; Mercenier; Myllyluoma; Rabot; Rafter; Szajewska; Watzl; Wells; Wolvers; Antoine (2010). "Guidance for substantiating the evidence for beneficial effects of probiotics: current status and recommendations for future research". J. Nutr. 140 (3): 671S–6S.  
  11. ^ Shane AL, Cabana MD, Vidry S, Merenstein D, Hummelen R, Ellis CL, Heimbach JT, Hempel S, Lynch SV, Sanders ME et al.: Guide to designing, conducting, publishing and communicating results of clinical studies involving probiotic applications in human participants. Gut Microbes 2010, 1:243-253
  12. ^ ftp://ftp.fao.org/es/esn/food/wgreport2.pdf Guidelines for the Evaluation of Probiotics in Food
  13. ^ a b Colin Hill, Francisco Guarner, Gregor Reid, Glenn R. Gibson, Daniel J. Merenstein, Bruno Pot, Lorenzo Morelli, Roberto Berni Canani, Harry J. Flint, Seppo Salminen, Philip C. Calder, Mary Ellen Sanders; Guarner; Reid; Gibson; Merenstein; Pot; Morelli; Canani; Flint; Salminen; Calder; Sanders (2014). "Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic". Nature Reviews Gastroenterology and Hepatology 11 (8): 506–514.  
  14. ^ a b c d Fuller R (May 1989). "Probiotics in man and animals". The Journal of Applied Bacteriology 66 (5): 365–78.  
  15. ^ a b Fuller R (1991). "Probiotics in human medicine". Gut 32 (4): 439–42.  
  16. ^ Fuller R. Probiotics the Scientific Thesis. London: Chapman & Hall, 1992
  17. ^ Review of probiotics available to modify gastrointestinal flora, Gismondo, 1999
  18. ^ Quigley EMM: The future of probiotics. In Probiotics in Pediatric Medicine. Edited by Michail S, Sherman P. Totowa, NJ: Humana Press; 2008:323-329
  19. ^ Reid G, Gaudier E, Guarner F, Huffnagle GB, Macklaim JM, Munoz AM, Martini M, Ringel-Kulka T, Sartor B, Unal R, Verbeke K, Walter J; Gaudier; Guarner; Huffnagle; MacKlaim; Munoz; Martini; Ringel-Kulka; Sartor; Unal; Verbeke; Walter; International Scientific Association for Probiotics Prebiotics (2010). "Responders and non-responders to probiotic interventions: how can we improve the odds?". Gut Microbes 1 (3): 200–4.  
  20. ^ O'Hara AM, O'Regan P, Fanning A, O'Mahony C, Macsharry J, Lyons A, Bienenstock J, O'Mahony L, Shanahan F; O'Regan; Fanning; O'Mahony; MacSharry; Lyons; Bienenstock; O'Mahony; Shanahan (2006). "Functional modulation of human intestinal epithelial cell responses by Bifidobacterium infantis and Lactobacillus salivarius". Immunology 118 (2): 202–15.  
  21. ^ (SCAN, 2000)
  22. ^ http://www.efsa.europa.eu/de/scdocs/doc/587.pdf Introduction of a Qualified Presum ption of Safety (QPS) approach for assessment of selected microorganisms referred to EFSA
  23. ^ Gismondo MR, Drago L, Lombardi A; Drago; Lombardi (1999). "Review of probiotics available to modify gastrointestinal flora". Int. J. Antimicrob. Agents 12 (4): 287–92.  
  24. ^ Azizpour K, Bahrambeygi S, Mahmoodpour S (2009). "History and Basic of Probiotics". Research Journal of Biological Sciences 4 (4): 409–426. 
  25. ^ Arteriosclerosis and intestinal poisons. [a contemporary review of Metchnikoff's work] JAMA 1910, 55:2311-12.
  26. ^ Vaughan RB (July 1965). "The romantic rationalist: A study of Elie Metchnikoff". Medical History 9 (3): 201–15.  
  27. ^ Tissier, H. 1900. Recherchers sur la flora intestinale normale et pathologique du nourisson. Thesis, University of Paris, Paris, France.
  28. ^ Alfred Nißle, 1918, "Die antagonistische Behandlung chronischer Darmstörungen mit Colibakterien, Medizinische Klinik, 1918, Issue 2, pp. 29–33.
  29. ^ a b Cheplin HA, Rettger LF; Rettger (December 1920). "Studies on the Transformation of the Intestinal Flora, with Special Reference to the Implantation of Bacillus Acidophilus: II. Feeding Experiments on Man". Proceedings of the National Academy of Sciences of the United States of America 6 (12): 704–5.  
  30. ^ Rettger, L.F., W.N. Levy, L. Weinstein, and J.E. Weiss. 1935. Lactobacillus acidophilus and its therapeutic application. Yale University Press, New Haven.
  31. ^ Hamilton-Miller et al. 2003
  32. ^ Lilly DM, Stillwell RH; Stillwell (1965). "Probiotics: Growth-promoting factors produced by microorganisms". Science (New York, N.Y.) 147 (3659): 747–748.  
  33. ^ Sperti, G. S. (1971). Probiotics. West Point, CT: AVI Publishing Co.  
  34. ^ Parker, R. B. (1974). "Probiotics, the other half of the antibiotic story". Animal Nutrition and Health 29: 4–8. 
  35. ^ Tannock GW (September 2003). "Probiotics: time for a dose of realism". Current Issues in Intestinal Microbiology 4 (2): 33–42.  
  36. ^ Gueimonde M, Collado MC; Collado (2012). "Metagenomics and probiotics". Clinical Microbiology and Infection. 18 Suppl 4: 32–4.  
  37. ^ Mach T (November 2006). "Clinical usefulness of probiotics against chronic inflammatory bowel diseases". Journal of Physiology and Pharmacology. 57 Suppl 9: 23–33.  
  38. ^ Yan F, Polk DB; Polk (November 2006). "Probiotics as functional food in the treatment of diarrhea". Current Opinion in Clinical Nutrition and Metabolic Care 9 (6): 717–21.  
  39. ^ Reid G (September 2008). "Probiotic Lactobacilli for urogenital health in women". J. Clin. Gastroenterol. 42 (Suppl 3 Pt 2): S234–6.  
  40. ^ LA 104 and reducing intestinal discomfort pursuant to Article 13(5) of Regulation (EC) No 1924/2006 (example, search EFSA for other opinion reports on probiotics"Streptococcus thermophillus LA 103 and Lactococcus lactis LA 102, Lactobacillus helveticus LA 101, Bifidobacterium longum"Scientific Opinion on the substantiation of a health claim related to a combination of (PDF). European Food Safety Authority, EFSA Journal 2013;11(2):3085. Retrieved 2012-11-08. 
  41. ^ Ljungh A, Wadstrom T, ed. (2009). Lactobacillus Molecular Biology: From Genomics to Probiotics. Caister Academic Press.  
  42. ^ Gilliland SE, Walker DK; Walker (April 1990). "Factors to consider when selecting a culture of Lactobacillus acidophilus as a dietary adjunct to produce a hypocholesterolemic effect in humans". Journal of Dairy Science 73 (4): 905–11.  
  43. ^ http://www.who.int/foodsafety/publications/fs_management/en/probiotics.pdf
  44. ^ Rowland I, Capurso L, Collins K, Cummings J, Delzenne N, Goulet O, Guarner F, Marteau P, Meier R; Capurso; Collins; Cummings; Delzenne; Goulet; Guarner; Marteau; Meier (2010). "Current level of consensus on probiotic science: Report of an expert meeting-London, 23 November 2009". Gut Microbes 1 (6): 436–439.  
  45. ^ Sears, Cynthia L. (2005). "A dynamic partnership: Celebrating our gut flora". Anaerobe 11 (5): 247–51.  
  46. ^ Wu, G. D.; Chen, J.; Hoffmann, C.; Bittinger, K.; Chen, Y.-Y.; Keilbaugh, S. A.; Bewtra, M.; Knights, D.; Walters, W. A.; Knight, R.; Sinha, R.; Gilroy, E.; Gupta, K.; Baldassano, R.; Nessel, L.; Li, H.; Bushman, F. D.; Lewis, J. D. (2011). "Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes". Science 334 (6052): 105–8.  
  47. ^ a b  
  48. ^ Million M, Raoult D; Raoult (February 2013). "Species and strain specificity of Lactobacillus probiotics effect on weight regulation". Microbial Pathogenesis 55: 52–4.  
  49. ^ Million M, Angelakis E, Paul M, Armougom F, Leibovici L, Raoult D; Angelakis; Paul; Armougom; Leibovici; Raoult (August 2012). "Comparative meta-analysis of the effect of Lactobacillus species on weight gain in humans and animals". Microbial Pathogenesis 53 (2): 100–8.  
  50. ^ Lahtinen SJ, Davis E, Ouwehand AC; Davis; Ouwehand (September 2012). "Lactobacillus species causing obesity in humans: where is the evidence?". Beneficial Microbes 3 (3): 171–4.  
  51. ^ a b Cuello-Garcia CA, Brożek JL, Fiocchi A, Pawankar R, Yepes-Nuñez JJ, Terracciano L, Gandhi S, Agarwal A, Zhang Y, Schünemann HJ (2015). "Probiotics for the prevention of allergy: A systematic review and meta-analysis of randomized controlled trials". J. Allergy Clin. Immunol. (Systematic review & meta-analysis).  
  52. ^ King CK, Glass R, Bresee JS, Duggan C; Glass; Bresee; Duggan; Centers for Disease Control Prevention (November 2003). "Managing acute gastroenteritis among children: oral rehydration, maintenance, and nutritional therapy". MMWR Recomm Rep 52 (RR–16): 1–16.  
  53. ^ Allen SJ, Martinez EG, Gregorio GV, Dans LF; Martinez; Gregorio; Dans (2010). Allen, Stephen J, ed. "Probiotics for treating acute infectious diarrhea". Cochrane Database Syst Rev 11 (11): CD003048.  
  54. ^ "'"Probiotics 'ease upset stomachs. NHS Choices. 2010. Retrieved 28 October 2013. 
  55. ^ a b Johnston BC, Goldenberg JZ, Vandvik PO, Sun X, Guyatt GH; Goldenberg; Vandvik; Sun; Guyatt (2011). "Probiotics for the prevention of pediatric antibiotic-associated diarrhea". Cochrane Database Syst Rev (11): CD004827.  
  56. ^ Szajewska H, Ruszczyński M, Radzikowski A; Ruszczyński; Radzikowski (2006). "Probiotics in the prevention of antibiotic-associated diarrhea in children: a meta-analysis of randomized controlled trials". J. Pediatr. 149 (3): 367–372.  
  57. ^ McFarland LV (2006). "Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease". Am. J. Gastroenterol. 101 (4): 812–22.  
  58. ^ Segarra-Newnham M (2007). "Probiotics for Clostridium difficile-Associated Diarrhea: Focus on Lactobacillus rhamnosus GG and Saccharomyces boulardii". Annals of Pharmacotherapy 41 (7): 1212–1221.  
  59. ^
    • D'Souza AL, Rajkumar C, Cooke J, Bulpitt CJ; Rajkumar; Cooke; Bulpitt (June 2002). "Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis". BMJ 324 (7350): 1361.  
    • Cremonini F, Di Caro S, Nista EC, Bartolozzi F, Capelli G, Gasbarrini G, Gasbarrini A; Di Caro; Nista; Bartolozzi; Capelli; Gasbarrini; Gasbarrini (August 2002). "Meta-analysis: the effect of probiotic administration on antibiotic-associated diarrhoea". Aliment. Pharmacol. Ther. 16 (8): 1461–7.  
    • McFarland LV (April 2006). "Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease". Am J Gastroenterol 101 (4): 812–22.  
    • Szajewska H, Mrukowicz J; Mrukowicz (2005-09-01). "Meta-analysis: non-pathogenic yeast Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea". Aliment Pharmacol Ther 22 (5): 365–72.  
    • Szajewska H, Ruszczyński M, Radzikowski A; Ruszczyński; Radzikowski (September 2006). "Probiotics in the prevention of antibiotic-associated diarrhea in children: a meta-analysis of randomized controlled trials". J Pediatr 149 (3): 367–372.  
    • Sazawal S, Hiremath G, Dhingra U, Malik P, Deb S, Black RE; Hiremath; Dhingra; Malik; Deb; Black (June 2006). "Efficacy of probiotics in prevention of acute diarrhoea: a meta-analysis of masked, randomised, placebo-controlled trials". Lancet Infect Dis 6 (6): 374–82.  
  60. ^ Arvola T, Laiho K, Torkkeli S, Mykkänen H, Salminen S, Maunula L, Isolauri E; Laiho; Torkkeli; Mykkänen; Salminen; Maunula; Isolauri (1999). "Prophylactic Lactobacillus GG reduces antibiotic-associated diarrhea in children with respiratory infections: A randomized study". Pediatrics 104 (5): e64.  
  61. ^ Doron SI, Hibberd PL, Gorbach SL; Hibberd; Gorbach (July 2008). "Probiotics for prevention of antibiotic-associated diarrhea". J Clin Gastroenterol 42 (Suppl 2): S58–63.  
  62. ^ Surawicz CM (July 2008). "Role of probiotics in antibiotic-associated diarrhea, Clostridium difficile-associated diarrhea, and recurrent Clostridium difficile-associated diarrhea". J Clin Gastroenterol 42 (Suppl 2): S64–70.  
  63. ^ a b Sanders ME (February 2000). "Considerations for use of probiotic bacteria to modulate human health". The Journal of Nutrition 130 (2S Suppl): 384S–390S.  
  64. ^ Kumar M, Nagpal R, Kumar R, Hemalatha R, Verma V, Kumar A, Chakraborty C, Singh B, Marotta F, Jain S, Yadav H; Nagpal; Kumar; Hemalatha; Verma; Kumar; Chakraborty; Singh; Marotta; Jain; Yadav (2012). "Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases". Experimental Diabetes Research 2012: 902917.  
  65. ^ Agerholm-Larsen L, Bell ML, Grunwald GK, Astrup A; Bell; Grunwald; Astrup (2002). "The effect of a probiotic milk product on plasma cholesterol: a meta-analysis of short term intervention studies". European Journal of Clinical Nutrition 54 (11): 856–860.  
  66. ^ Kiessling G, Schneider J, Jahreis G; Schneider; Jahreis (2002). "Long term consumption of fermented dairy products over 6 months increases HDL cholesterol". European Journal of Clinical Nutrition 56 (9): 843–849.  
  67. ^ Khalesi S, Sun J, Buys N, Jayasinghe R (2014). "Effect of probiotics on blood pressure: a systematic review and meta-analysis of randomized, controlled trials". Hypertension (Systematic review & meta-analysis) 64 (4): 897–903.  
  68. ^ a b c d Reid G, Jass J, Sebulsky MT, McCormick JK; Jass; Sebulsky; McCormick (October 2003). "Potential uses of probiotics in clinical practice". Clin. Microbiol. Rev. 16 (4): 658–72.  
  69. ^ a b Ouwehand AC, Salminen S, Isolauri E; Salminen; Isolauri (August 2002). "Probiotics: an overview of beneficial effects" (PDF). Antonie Van Leeuwenhoek 82 (1–4): 279–89.  
  70. ^ Hatakka K, Savilahti E, Pönkä A, Meurman JH, Poussa T, Näse L, Saxelin M, Korpela R; Savilahti; Pönkä; Meurman; Poussa; Näse; Saxelin; Korpela (June 2001). "Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial". BMJ 322 (7298): 1327.  
  71. ^ Näse L, Hatakka K, Savilahti E, Saxelin M, Pönkä A, Poussa T, Korpela R, Meurman JH; Hatakka; Savilahti; Saxelin; Pönkä; Poussa; Korpela; Meurman (2001). "Effect of long-term consumption of a probiotic bacterium, Lactobacillus rhamnosus GG, in milk on dental caries and caries risk in children". Caries Research 35 (6): 412–20.  
  72. ^ Hamilton-Miller JM (October 2003). "The role of probiotics in the treatment and prevention of Helicobacter pylori infection". International Journal of Antimicrobial Agents 22 (4): 360–6.  
  73. ^ Kirjavainen PV, Salminen SJ, Isolauri E; Salminen; Isolauri (February 2003). "Probiotic bacteria in the management of atopic disease: underscoring the importance of viability". J. Pediatr. Gastroenterol. Nutr. 36 (2): 223–7.  
  74. ^ Braat H, van den Brande J, van Tol E, Hommes D, Peppelenbosch M, van Deventer S; Van Den Brande; Van Tol; Hommes; Peppelenbosch; Van Deventer (2004). "Lactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4+ T cells via modulation of dendritic cell function". The American journal of clinical nutrition 80 (6): 1618–25.  
  75. ^ Moayyedi P, Ford AC, Talley NJ, Cremonini F, Foxx-Orenstein AE, Brandt LJ, Quigley EM; Ford; Talley; Cremonini; Foxx-Orenstein; Brandt; Quigley (March 2010). "The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review". Gut (Systematic review) 59 (3): 325–32.  
  76. ^ Naidoo K, Gordon M, Fagbemi AO, Thomas AG, Akobeng AK; Gordon; Fagbemi; Thomas; Akobeng (2011). "Probiotics for maintenance of remission in ulcerative colitis". Cochrane Database Syst Rev (Systematic review) (12): CD007443.  
  77. ^ AlFaleh K. & Anabrees J., 2014, "Probiotics for prevention of necrotizing enterocolitis in preterm infants." Cochrane Database of Systematic Reviews Issue 4, Art. No.: CD005496, DOI 10.1002/14651858.CD005496.pub4, see [7], accessed 11 June 2015.
  78. ^ Cooke, G.; Behan, J.; Costello, M. (2006). "Newly identified vitamin K-producing bacteria isolated from the neonatal faecal flora". Microbial Ecology in Health and Disease 18 (3–4): 133.  
  79. ^ Strozzi GP, Mogna L; Mogna (2008). "Quantification of Folic Acid in Human Feces After Administration of Bifidobacterium Probiotic Strains". Journal of Clinical Gastroenterology 42: S179–S184.  
  80. ^ Molina VC, Médici M, Taranto MP, Font de Valdez G; Médici; Taranto; Font De Valdez (2009). "Lactobacillus reuteriCRL 1098 prevents side effects produced by a nutritional vitamin B12deficiency". Journal of Applied Microbiology 106 (2): 467–473.  
  81. ^ Petrova, Mariya I.; Lievens, Elke; Malik, Shweta; Imholz, Nicole; Lebeer, Sarah (2015). "Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health". Frontiers in Physiology 6.  
  82. ^ Borges S, Silva J, Teixeira P; Silva; Teixeira (March 2014). "The role of lactobacilli and probiotics in maintaining vaginal health". Arch. Gynecol. Obstet. (Review) 289 (3): 479–89.  
  83. ^ Besselink MG, van Santvoort HC, Buskens E, Boermeester MA, van Goor H, Timmerman HM, Nieuwenhuijs VB, Bollen TL, van Ramshorst B, Witteman BJ, Rosman C, Ploeg RJ, Brink MA, Schaapherder AF, Dejong CH, Wahab PJ, van Laarhoven CJ, van der Harst E, van Eijck CH, Cuesta MA, Akkermans LM, Gooszen HG; Van Santvoort; Buskens; Boermeester; Van Goor; Timmerman; Nieuwenhuijs; Bollen; Van Ramshorst; Witteman; Rosman; Ploeg; Brink; Schaapherder; Dejong; Wahab; Van Laarhoven; Van Der Harst; Van Eijck; Cuesta; Akkermans; Gooszen; Dutch Acute Pancreatitis Study Group (February 2008). "Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial". Lancet 371 (9613): 651–9.  
  84. ^ a b Bee, Peta (November 10, 2008). "Probiotics, Not so friendly after all". The Times (London). 
  85. ^ "So-called 'friendly' bacteria may be dangerous, according to new research - so which should you be taking?".  
  86. ^ Islam MA, Yun CH, Choi YJ, Cho CS; Yun; Choi; Cho (2010). "Microencapsulation of live probiotic bacteria" (PDF). Journal of Microbiology and Biotechnology 20 (1367–1377): 1367–1377.  
  87. ^ Khan M, Raoult D, Richeta H, Lepidia H, La Scola B; Raoult; Richet; Lepidi; La Scola (2007). "Growth-promoting effects of single-dose intragastrically administered probiotics in chickens". British Poultry Science 48 (6): 732–735.  
  88. ^ Raoult D (September 2009). "Probiotics and obesity : a link ?". Nature Reviews Microbiology 7 (9): 616.  
  89. ^ Raoult, Didier (2009). "No link between probiotics and obesity? Author reply" (PDF). Nature Reviews Microbiology 7 (12): 901.  
  90. ^ Ehrlich SD (2009). "Probiotics - little evidence for a link to obesity". Nature Reviews Microbiology 7 (12): 901; author reply 901.  
  91. ^ Bee, Peta (November 10, 2008). "Probiotics, not so friendly after all?". The Times (London). Retrieved 18 June 2010. 
  92. ^ Seseña S, Palop ML; Palop (2007). "An ecological study of lactic acid bacteria from Almagro eggplant fermentation brines". Journal of Applied Microbiology (Blackwell Publishing) 103 (5): 1553–1561.  
  93. ^ a b Frederick, Breidt, Jr; et al. (2007). "Fermented Vegetables" (PDF). ASM Press. Retrieved 7 November 2007. 
  94. ^ Ji, Feng-Di; Ji, B.-P.; Li, B.; Han, B.-Z. (2007). "Note. Microbial Changes During the Salting Process of Traditional Pickled Chinese Cabbage". Food Science and Technology International (SAGE Publications) 13 (1): 11–16.  
  95. ^ a b c Kumar M, Ghosh M, Ganguli A; Ghosh; Ganguli (2012). "Mitogenic response and probiotic characteristics of lactic acid bacteria isolated from indigenously pickled vegetables and fermented beverages". World journal of microbiology & biotechnology 28 (2): 703–11.  
  96. ^ Moreno MR, Leisner JJ, Tee LK, Ley C, Radu S, Rusul G, Vancanneyt M, De Vuyst L; Leisner; Tee; Ley; Radu; Rusul; Vancanneyt; De Vuyst (2002). "Microbial analysis of Malaysian tempeh, and characterization of two bacteriocins produced by isolates of Enterococcus faecium". Journal of Applied Microbiology (The Microbiology Research Foundation) 92 (1): 147–157.  
  97. ^ Ehrlich, Steven D. (2011-05-24). "Lactobacillus acidophilus". University of Maryland Medical Center (UMMC). Retrieved 2015-09-17. 
  98. ^ Plessas S, Alexopoulos A, Voidarou C, Stavropoulou E, Bezirtzoglou E; Alexopoulos; Voidarou; Stavropoulou; Bezirtzoglou (2011). "Microbial ecology and quality assurance in food fermentation systems. The case of kefir grains application". Anaerobe 17 (6): 483–5.  
  99. ^ Shiby VK, Mishra HN; Mishra (2013). "Fermented milks and milk products as functional foods--a review". Critical reviews in food science and nutrition 53 (5): 482–96.  
  100. ^ Oh CK, Oh MC, Kim SH; Oh; Kim (2004). "The Depletion of Sodium Nitrite by Lactic Acid Bacteria Isolated from Kimchi". Journal of Medicinal Food ( 
  101. ^ Pederson CS, Niketic G, Albury MN; Niketic; Albury (1962). "Fermentation of the Yugoslavian pickled cabbage". Applied microbiology 10 (1): 86–9.  
  102. ^ Friedman, Y; Hugenholtz, Jeroen; De Vos, Willem M.; Smid, Eddy J. (2006). "Safe use of genetically modified lactic acid bacteria in food. Bridging the gap between consumers, green groups, and industry". Electronic Journal of Biotechnology (Pontificia Universidad Católica de Valparaíso) 9 (4): E49–55.  
  103. ^ Tanasupawat S, Thongsanit J, Okada S, Komagata K; Thongsanit; Okada; Komagata (2002). "Lactic acid bacteria isolated from soy sauce mash in Thailand". Journal of General and Applied Microbiology (The Microbiology Research Foundation) 48 (4): 201–209.  
  104. ^ "Live & Active Culture Yogurt". Retrieved 12 December 2014. 
  105. ^ Guidelines for the Evaluation of Probiotics in Food, Report of a Joint FAO/WHO Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food (PDF) (Report). London, Ontario, Canada: Food and Agriculture Organization and World Health Organization. April 2002. Retrieved 12 December 2014. 
  106. ^ Sanders, ME (2000). "Considerations for Use of Probiotic Bacteria to Modulate Human Health". The Journal of Nutrition 130 (2S Suppl): 384S–390S.  
  107. ^ ‘Probiotic’ As A General Descriptor (PDF) (Report). Yogurt & Live Fermented Milks Association (YLFA). Retrieved 12 December 2014. 
  108. ^ "Regulation (EC) No 1924/2006 of the European Parliament and of the Council on 20 December 2006 on nutrition and health claims made on foods". European Commission, Brussels. 2006. Retrieved 13 December 2014. 
  109. ^ "Probiotic health claims". Food Safety Authority of Ireland, Dublin. 2014. Retrieved 13 December 2014. 
  110. ^ Zonis S (2008). "What is Probiotic Food? An Introduction To The World of Probiotics: Have You Had Your Friendly Bacteria Today?". The Nibble. Retrieved 12 December 2014. 
  111. ^ "Bifidobacterium". WebMD. 2014. Retrieved 12 December 2014. 
  112. ^ a b c "Probiotic market: global sales by region 2010-2015 (fee-based)". Statista. 2014. Retrieved 12 December 2014. ()
  113. ^ EFSA calls for characterisation work as probiotic resubmissions loom
  114. ^ Timmerman HM, Koning CJ, Mulder L, Rombouts FM, Beynen AC; Koning; Mulder; Rombouts; Beynen (November 2004). "Monostrain, multistrain and multispecies probiotics—A comparison of functionality and efficacy". Int. J. Food Microbiol. 96 (3): 219–33.  
  115. ^ Williams EA, Stimpson J, Wang D, Plummer S, Garaiova I, Barker ME, Corfe BM; Stimpson; Wang; Plummer; Garaiova; Barker; Corfe (September 2008). "Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study". Aliment. Pharmacol. Ther. 29 (1): 97–103.  

References

See also

Preliminary research is evaluating the potential physiological effects of multiple probiotic strains, as opposed to a single strain.[114][115] As the human gut may contain several hundred microbial species, one theory indicates that this diverse environment may benefit from consuming multiple probiotic strains, an effect that remains scientifically unconfirmed.

Multiple probiotics

The European Food Safety Authority has so far rejected 260 claims[113] on probiotics in Europe due to insufficient research and thus inconclusive proof. The review did not refute the potential for effectiveness, but rather that a cause-effect relationship had not been sufficiently established in studies to date.

EFSA scientific review of probiotics

Sales of probiotic products have a rising trend from 2010 to 2014, increasing globally by 35% from US$23.1 billion to $31.3 billion.[112] Some regions have increased their use by even more than the average, including Eastern Europe (67%), Asia Pacific (67%), and Latin America (47%), comprising nearly half of probiotics sold globally in 2014.[112] By geographic region, the leading consumers of probiotics in 2014 were Western Europe ($8.3 billion), Asia Pacific ($7 billion), Japan ($5.4 billion), Latin America ($4.8 billion), North America ($3.5 billion), and Eastern Europe ($2.3 billion).[112]

Global consumption

The first commercially sold dairy-based probiotic was Yakult, a fermented milk with added Lactobacillus casei Shirota, in 1935. Since then, many more probiotic foods have come on the market, mostly in the form of dairy products. Recently, nondairy and unfermented probiotics have been produced, including breakfast cereal and snack bars, whereas other probiotic products include kefir, yogurt, kombucha, kimchi, sauerkraut, and other fermented foods and beverages.[110][111]

History and modern products

[109][108] because such labeling misleads consumers to believe a health benefit is provided by the product when no scientific proof exists to demonstrate that health effect.[107] placed a ban on putting the word “probiotic” on the packaging of productsEuropean Commission Because of variability in storage conditions and time before eating, it is difficult to tell exactly how much active culture remains at the time of consumption. Due to these ambiguities, in 2012, the [106] but most companies that give a number report the viable cell count at the date of manufacture, a number probably much higher than existing at the moment of consumption.[105] In 2002, the US [104] CFU/mL cultures per gram (at the time of manufacture).8 The National Yogurt Association gives a Live & Active Cultures seal to yogurt products which contain 10

Labeling ambiguities

Commercial probiotics

Some fermented products are reported to contain similar lactic acid bacteria, including pickled vegetables,[92][93][94][95] fermented bean paste such as tempeh,[96] miso,[97] and doenjang, kefir,[98] buttermilk or karnemelk,[99] kimchi [93][100] pao cai,[95][101] sauerkraut,[102] soy sauce,[103] and zha cai.[95]

For the variety of strains with imputed potential health benefits, see the research section above. Some additional forms of lactic acid bacteria include Lactobacillus bulgaricus, Streptococcus thermophilus, and "Lactobacillus bifidus".

Only preliminary evidence exists for most probiotic health claims. Even for the most studied strains, few have been sufficiently developed in basic and clinical research to warrant approval for health claim status to a regulatory agency such as the Food and Drug Administration or European Food Safety Authority, and to date, no claims have been approved by those two agencies.

Live probiotic cultures are available in fermented dairy products and probiotic fortified foods. However, tablets, capsules, powders, and sachets containing the bacteria in freeze-dried form are also available.

Strains

Some experts are skeptical on the efficacy of many strains and believe not all subjects will benefit from the use of probiotics.[91]

One 2009 paper cited a 2007 study in chickens [87] as a support for causally linked probiotic products such as yogurts with obesity trends.[88] However, this is contested as the link to obesity, and other health-related issues with yogurt may link to its dairy and calorie attributes.[89][90]

Probiotics taken orally can be destroyed by the acidic conditions of the stomach. A number of microencapsulation techniques are being developed to address this problem.[86]

Some hospitals have reported treating Lactobacillus septicaemia, which is a potentially fatal disease caused by the consumption of probiotics by people with lowered immune systems or who are already very ill.[84][85]

In a clinical trial aimed at showing the effectiveness of probiotics in reducing childhood allergies, researchers gave 178 children either a probiotic or a placebo for the first six months of their lives. Those given the probiotic were more likely to develop a sensitivity to allergens.[84]

In some situations, such as where the person consuming probiotics is critically ill, probiotics could be harmful. In a therapeutic clinical trial conducted by the Dutch Pancreatitis Study Group, the consumption of a mixture of six probiotic bacteria increased the death rate of patients with predicted severe acute pancreatitis.[83]

Side effects

[82], preventing and alleviating bacterial vaginosis.vaginal flora and rebalance pH, were able to normalize vaginal L. rhamnosus and L. acidophilus producing strains, such as hydrogen peroxide In 2013, researchers found that administration of [81] Probiotic treatment of bacterial vaginosis is the application or ingestion of

Bacterial Vaginosis

Probiotics are commonly given to breast-feeding mothers and their young children to prevent eczema, but some doubt exists over the strength of evidence supporting this practice.[51]

Eczema

Probiotic treatment has been studied as a means of addressing maladies associated with vitamin deficiency, e.g., of vitamin K,[78] folic acid,[79] and vitamin B12.[80]

Vitamin production

Several clinical studies provide evidence for the potential of probiotics to lower the risk of necrotizing enterocolitis (NEC) and mortality in premature infants. One meta-analysis indicated that probiotics reduce all-cause mortality and risk of having NEC by more than 50% compared with controls.[77]

Necrotizing enterocolitis

No good evidence indicates taking probiotics helps maintain remission from ulcerative colitis.[76]

Probiotics may help people with irritable bowel syndrome, although uncertainty remains around which type of probiotic works best, and around the size of the effect.[75]

Irritable bowel syndrome and colitis

Some strains of LAB may modulate inflammatory and hypersensitivity responses, an observation thought to be at least in part due to the regulation of cytokine function.[68] Clinical studies suggest they can prevent reoccurrences of inflammatory bowel disease in adults,[68] as well as improve milk allergies.[73] How probiotics may influence the immune system remains unclear, but a potential mechanism under research concerns the response of T lymphocytes to proinflammatory stimuli.[74]

Inflammation

Some strains of LAB may affect Helicobacter pylori infections (which may cause peptic ulcers) in adults when used in combination with standard medical treatments, but no standard in medical practice or regulatory approval exists for such treatment.[72]

Helicobacter pylori

Some strains of LAB may affect pathogens by means of competitive inhibition (i.e., by competing for growth) and some evidence suggests they may improve immune function by increasing the number of IgA-producing plasma cells and increasing or improving phagocytosis, as well as increasing the proportion of T lymphocytes and natural killer cells.[68][69] Clinical trials have demonstrated that probiotics may decrease the incidence of respiratory-tract infections[70] and dental caries in children.[71] LAB products might aid in the treatment of acute diarrhea, and possibly affect rotavirus infections in children and travelers' diarrhea in adults,[68][69] but no products are approved for such indications.

Immune function and infections

The consumption of probiotics may effect a modest benefit in helping to control high blood pressure.[67]

Blood pressure

Studies specifically on hyperlipidemic subjects are still needed.

A slightly longer study evaluating the effect of a yogurt with probiotic strains on 29 subjects over six months found no statistically significant differences in total serum cholesterol or LDL values. However, the study did note a significant increase in serum HDL from, 50 to 62 mg/dL (1.28 to 1.6 mmol/L) following treatment. This corresponds to a possible improvement of LDL/HDL ratio.[66]

A meta-analysis that included five double-blind trials examining the short-term (2–8 weeks) effects of a yogurt with probiotic strains on serum cholesterol levels found a minor change of 8.5 mg/dL (0.22 mmol/L) (4% decrease) in total cholesterol concentration, and a decrease of 7.7 mg/dL (0.2 mmol/L) (5% decrease) in serum LDL concentration.[65]

Preliminary human and animal studies have demonstrated the efficacy of some strains of lactic acid bacteria (LAB) for reducing serum cholesterol levels, presumably by breaking down bile in the gut, thus inhibiting its reabsorption (where it enters the blood as cholesterol).[63][64]

Cholesterol

Ingestion of certain active strains may help lactose-intolerant individuals tolerate more lactose than they would otherwise have tolerated.[63]

Lactose intolerance

The potential efficacy of probiotic AAD prevention is dependent on the probiotic strain(s) used and on the dosage.[61][62] A Cochrane Collaboration systematic review, in which 16 randomized clinical trials (n=3432 participants) were analyzed, concluded that treatments with less than 5000 million CFUs/day did not show a significant decrease of AAD. However, patients treated with ≥5000 million CFUs/day (including L. rhamnosus and Saccharomyces boulardii) had 60% lower relative risk (95%CI: 44–71%) of experiencing AAD than untreated patients.[55]

Probiotic treatment might reduce the incidence and severity of AAD as indicated in several meta-analyses.[59] For example, treatment with probiotic formulations including L. rhamnosus may reduce the risk of AAD, improve stool consistency during antibiotic therapy, and enhance the immune response after vaccination.[60] However, further documentation of these findings through randomized, double-blind, placebo-controlled trials is required to confirm specific effects and obtain regulatory approval, which currently does not exist.

Some of the best evidence in support of probiotic health benefits is in the treatment of Clostridium difficile.[58]

Antibiotic-associated diarrhea

Some probiotics are suggested as a possible treatment for various forms of gastroenteritis,[52] and a Cochrane Collaboration meta-analysis on the use of probiotics to treat acute infectious diarrhea based on a comprehensive review of medical literature through 2010 (35 relevant studies, >4500 participants) reported that use of any of the various tested probiotic formulations appeared to reduce the duration of diarrhea by a mean of 25 hours (vs. control groups, 95% confidence interval, 16–34 hours), also noting, however, that "the differences between the studies may be related to other unmeasured and unexplored environmental and host factors" and that further research was needed to confirm reported benefits.[53][54]

Diarrhea

Probiotics are ineffective in preventing allergies in children, with the possible exception of eczema.[51]

Allergies

Claims that some lactobacilli may contribute to weight gain in some humans[48][49] remain controversial.[50]

In a 2009 blog post, one expert reasoned that preliminary clinical results exist for some applications, such as treating diarrhea, but wider health benefits claimed by probiotic proponents lack plausibility since the body's "ecosystem" is sufficiently complex that adding a few bacteria is unlikely to have the claimed effect. Accordingly, he reasoned, "the alleged health benefits of probiotics are often an example of spin".[47] Since then, there has been an increase in the body of scientific evidence supporting the use of specific probiotics to improve health. Although the body's complex microbial community is incompletely understood at present, there is strong scientific consensus on the benefits of using of probiotics to address certain medical states or conditions.[13]

Although research does suggest that the relationship between gut flora and humans is a mutualistic relationship,[45] very little evidence supports claims that probiotic dietary supplements have any health benefits.[5] Improved health through gut flora modulation appears to be directly related to long-term dietary changes.[46]

Research into the potential health effects of supplemental probiotics has included the molecular biology and genomics of Lactobacillus in immune function, cancer, and antibiotic-associated diarrhea, travellers' diarrhea, pediatric diarrhea, inflammatory bowel disease, and irritable bowel syndrome.[41] Testing of a probiotic applies to a specific strain under study.[42] The scientific community cautions against extrapolating an effect from a tested strain to an untested strain.[43][44]

Studies are examining whether probiotics affect mechanisms of intestinal inflammation,[37] diarrhea,[38] or urogenital infections.[39] Through 2012, however, in all cases proposed as health claims to the European Food Safety Authority, the scientific evidence remains insufficient to prove a cause-and-effect relationship between consumption of probiotic products and any health benefit.[1][40]

Probiotics are under considerable research, as the concept holds promise for human health and well-being, and corresponding commercial opportunities. Protection of consumers requires health claims to be confirmed with sufficient scientific evidence. Overall scientific demonstration of probiotic effects requires defining a healthy microbiota and interactions between microbiota and host, and the difficulty to characterize probiotic effectiveness in health and disease. Recent developments of high-throughput sequencing technology and the consequent progresses of metagenomics represent a new approach for the future of probiotics research.[36]

Research

In the following decades, intestinal lactic acid bacterial species with alleged health beneficial properties have been introduced as probiotics, including Lactobacillus rhamnosus, Lactobacillus casei, and Lactobacillus johnsonii.[35]

The term "probiotic" originally referred to microorganisms that have effects on other microorganisms.[32] The conception of probiotics involved the notion that substances secreted by one microorganism stimulated the growth of another microorganism. The term was used again[33] to describe tissue extracts which stimulated microbial growth. The term probiotics was taken up by Parker,[34] who defined the concept as, “organisms and substances that have a beneficial effect on the host animal by contributing to its intestinal microbial balance”. Later, the definition was greatly improved by Fuller,[14] whose explanation was very close to the definition used today. Fuller 89 described probiotics as a "live microbial feed supplement which beneficially affects the host animal by improving its intestinal microbial balance". He stressed two important facts of probiotics: the viable nature of probiotics and the capacity to help with intestinal balance.

According to Hamilton-Miller et al.,[31] in a letter in which they call for the oldest known citation of the word, the term "probiotics" was first introduced in 1953 by A live microbial feed supplement which beneficially affects the host animal by improving its intestinal microbial balance".[14] Fuller's definition emphasizes the requirement of viability for probiotics and introduces the aspect of a beneficial effect on the host.

In 1920, Rettger and Cheplin reported that Metchnikoff's "Bulgarian Bacillus", later called constipation.

During an outbreak of shigellosis in 1917, German professor Alfred Nissle isolated a strain of Escherichia coli from the feces of a soldier who was not affected by the disease.[28] Methods of treating infectious diseases were needed at that time when antibiotics were not yet available, and Nissle used the E. coli Nissle 1917 strain in acute gastrointestinal infectious salmonellosis and shigellosis.

Bifidobacteria were first isolated from a breast-fed infant by Henry Tissier, who also worked at the Pasteur Institute. The isolated bacterium named Bacillus bifidus communis[27] was later renamed to the genus Bifidobacterium. Tissier found that bifidobacteria are dominant in the gut flora of breast-fed babies and he observed clinical benefits from treating diarrhea in infants with bifidobacteria. The claimed effect was bifidobacterial displacement of proteolytic bacteria causing the disease.

It was at that time known that milk fermented with lactic-acid bacteria inhibits the growth of proteolytic bacteria because of the low pH produced by the fermentation of lactose. Metchnikoff had also observed that certain rural populations in Europe, for example in Bulgaria and the Russian steppes, who lived largely on milk fermented by lactic-acid bacteria were exceptionally long lived. Based on these observations, Metchnikoff proposed that consumption of fermented milk would "seed" the intestine with harmless lactic-acid bacteria and decrease the intestinal pH, and that this would suppress the growth of proteolytic bacteria. Metchnikoff himself introduced in his diet sour milk fermented with the bacteria he called "Bulgarian Bacillus" and found his health benefited. Friends in Paris soon followed his example and physicians began prescribing the sour-milk diet for their patients.[26]

The original modern hypothesis of the positive role played by certain bacteria was first introduced by Russian scientist and Nobel laureate Élie Metchnikoff, who in 1907 suggested that it would be possible to modify the gut flora and to replace harmful microbes with useful microbes.[3] Metchnikoff, at that time a professor at the Pasteur Institute in Paris, proposed the hypothesis that the aging process results from the activity of putrefactive (proteolytic) microbes producing toxic substances in the large bowel. Proteolytic bacteria such as clostridia, which are part of the normal gut flora, produce toxic substances including phenols, indols, and ammonia from the digestion of proteins. According to Metchnikoff, these compounds were responsible for what he called "intestinal autointoxication", which would cause the physical changes associated with old age.[25]

Probiotics have received renewed attention recently from product manufacturers, research studies, and consumers. The history of probiotics can be traced to the first use of cheese and fermented products, that were well known to the Greeks and Romans who recommended their consumption.[23] The fermentation of dairy foods represents one of the oldest techniques for food preservation.[24]

History

Finally, probiotics must be supplied in adequate numbers, which may be defined as the number able to trigger the targeted effect on the host. It depends on strain specificity, process, and matrix, as well as the targeted effect. Most of reported benefits demonstrated with the traditional probiotics have been observed after ingestion of a concentration around 107 to 108 probiotic cells per gram, with a serving size around 100 to 200 mg per day.[10]

In Europe, EFSA has adopted a premarket system for safety assessment of microbial species used in food and feed productions, to set priorities for the need of risk assessment. The assessment is made for a selected group of microorganisms, which if favorable, leads to the “Qualified Presumption of Safety” status.[22]

  • Determination of antibiotic resistance patterns
  • Assessment of certain metabolic activities (e.g., D-lactate production, bile salt deconjugation)
  • Assessment of side effects during human studies
  • Epidemiological surveillance of adverse incidents in consumers (after market)
  • If the strain under evaluation belongs to a species that is a known mammalian toxin producer, it must be tested for toxin production. One possible scheme for testing toxin production has been recommended by the EU Scientific Committee on Animal Nutrition[21]
  • If the strain under evaluation belongs to a species with known hemolytic potential, determination of hemolytic activity is required

Probiotics must be safe for their intended use. The 2002 FAO/WHO guidelines recommend that, though bacteria may be generally recognized as safe (GRAS), the safety of the potential probiotic should be assessed by the minimum required tests:

[10] The probiotic candidate must be a taxonomically defined microbe or combination of microbes (

Probiotics have to be alive when administered.[14][15][16] One of the concerns throughout the scientific literature resides in the viability and reproducibility on a large scale of the observed results, as well as the viability and stability during use and storage, and finally the ability to survive in stomach acids and then in the intestinal ecosystem.[17] Probiotics must have undergone controlled evaluation to document health benefits in the target host. Only products containing live organisms shown in reproducible human studies to confer a health benefit can actually claim to be a probiotic.[18][19][20] The correct definition of health benefit, backed with solid scientific evidence, is a strong element for the proper identification and assessment of the effect of a probiotic. This aspect represents a major challenge for scientific and industrial investigations because several difficulties arise, such as variability in the site for probiotic use (oral, vaginal, intestinal) and mode of application.[14]

A group of scientific experts assembled in London, UK, on October 23, 2013, to discuss the scope and appropriate use of the term probiotic. The meeting was motivated by developments in the field since 2001. The panel's conclusions were published in June, 2014.[13]

This effort is accompanied by local governmental and supra-governmental regulatory bodies requirements to better characterize health claims substantiations. [12] The FAO/WHO consultation was also a first effort towards the assessment of probiotics efficacy and resulted in May 2002 in a document named “Guidelines for the Evaluation of Probiotics in Food”.[2] A consensus definition of the term “probiotics”, based on the available information and scientific evidence, was adopted after a joint

The [9] Following this definition, a working group convened by the FAO/WHO in May 2002 issued the “Guidelines for the Evaluation of Probiotics in Food”. This first global effort was further developed in 2010, two expert groups of academic scientists and industry representatives made recommendations for the evaluation and validation of probiotic health claim.[10][11] The same principles emerged from those groups as the ones expressed in the Guidelines of FAO/WHO in 2002. This definition, although widely adopted, is not acceptable to the European Food Safety Authority because it embeds a health claim which is not measurable.[1]

Definition

Some literature gives it a full Greek etymology,[6][7] but the term appears to be a composite of the Latin preposition pro ("for") and the Greek adjective βιωτικός (biotic), the latter deriving from the noun βίος (bios, "life").[8]

Etymology

Contents

  • Etymology 1
  • Definition 2
  • History 3
  • Research 4
    • Allergies 4.1
    • Diarrhea 4.2
      • Antibiotic-associated diarrhea 4.2.1
    • Lactose intolerance 4.3
    • Cholesterol 4.4
    • Blood pressure 4.5
    • Immune function and infections 4.6
    • Helicobacter pylori 4.7
    • Inflammation 4.8
    • Irritable bowel syndrome and colitis 4.9
    • Necrotizing enterocolitis 4.10
    • Vitamin production 4.11
    • Eczema 4.12
    • Bacterial Vaginosis 4.13
  • Side effects 5
  • Strains 6
  • Commercial probiotics 7
    • Labeling ambiguities 7.1
    • History and modern products 7.2
    • Global consumption 7.3
  • EFSA scientific review of probiotics 8
  • Multiple probiotics 9
  • See also 10
  • References 11
  • Further reading 12

Scientific evidence to date has been insufficient to substantiate any antidisease claims or health benefits from consuming probiotics.[1][4][5]

Commonly claimed benefits of probiotics include the decrease of potentially pathogenic gastrointestinal microorganisms, the reduction of gastrointestinal discomfort, the strengthening of the immune system, the improvement of the skin's function, the improvement of bowel regularity, the strengthening of the resistance to cedar pollen allergens, the decrease in body pathogens, the reduction of flatulence and bloating, the protection of DNA, the protection of proteins and lipids from oxidative damage, and the maintaining of individual intestinal microbiota in subjects receiving antibiotic treatment.

Studies on the medical benefits of probiotics have yet to reveal a cause-effect relationship, and their medical effectiveness has yet to be conclusively proven for most of the studies conducted thus far. [1]