Nisoldipine

Nisoldipine

Nisoldipine
Systematic (IUPAC) name
isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Clinical data
Trade names Sular
AHFS/Drugs.com
MedlinePlus
Pregnancy cat.
Legal status
Routes Oral
Pharmacokinetic data
Protein binding 99%
Half-life 7-12 hours
Identifiers
CAS number  Y
ATC code C08
PubChem
IUPHAR ligand
DrugBank
ChemSpider  N
UNII  N
KEGG  Y
ChEBI  N
ChEMBL  N
Chemical data
Formula C20H24N2O6 
Mol. mass 388.414 g/mol
 N   

Nisoldipine (INN) is a calcium channel blocker of the dihydropyridine class. It sold in the United States under the proprietary name Sular. Nisoldipine has tropism for cardiac blood vessels. [1]

External links

  • DDB 30009
  • Mielcarek J, Grobelny P, Szamburska O (2005). "The effect of beta-carotene on the photostability of nisoldipine.". Methods Find Exp Clin Pharmacol 27 (3): 167–71. PMID 15834448. doi:10.1358/mf.2005.27.3.890873. 
  • Missan S, Zhabyeyev P, Dyachok O, Jones SE, McDonald TF (November 2003). "Block of cardiac delayed-rectifier and inward-rectifier K+ currents by nisoldipine". Br. J. Pharmacol. 140 (5): 863–70. PMC 1574108. PMID 14530219. doi:10.1038/sj.bjp.0705518. 
  • Hamilton S, Houle L, Thadani U (1999). "Rapid-release and coat-core formulations of nisoldipine in treatment of hypertension, angina, and heart failure.". Heart Dis 1 (5): 279–88. PMID 11720635. 

References

  1. ^ http://www.sciencedirect.com/science/article/pii/S0002914999804469 Why is nisoldipine a specific agent in ischemic left ventricular dysfunction?