MT-TK

MT-TK

mitochondrially encoded tRNA lysine
Identifiers
Symbol MT-TK
Alt. symbols MERRF, MTTK
Entrez HUGO RefSeq Locus [1]

Mitochondrially encoded tRNA lysine also known as MT-TK is a transfer RNA which in humans is encoded by the mitochondrial MT-TK gene.[1]

Function

MT-TK is a small 70 nucleotide RNA (human mitochondrial map position 8295-8364) that transfers the amino acid lysine to a growing polypeptide chain at the ribosome site of protein synthesis during translation.

Clinical significance

Mutations in the MT-TK gene are associated with myoclonic epilepsy and ragged-red fiber disease (MERRF).[2][3]

References

External links

  • GeneReviews/NCBI/NIH/UW entry on Mitochondrial DNA-Associated Leigh Syndrome and NARP