Symbols  ; MTND2
External IDs ChEMBL: GeneCards:
Species Human Mouse
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a
Location (UCSC)
PubMed search

NADH-ubiquinone oxidoreductase chain 2 is an enzyme that in humans is encoded by the MT-ND2 gene.

Further reading

  • Torroni A, Achilli A, Macaulay V, et al. (2006). "Harvesting the fruit of the human mtDNA tree.". Trends Genet. 22 (6): 339–45. PMID 16678300. doi:10.1016/j.tig.2006.04.001. 
  • Bodenteich A, Mitchell LG, Polymeropoulos MH, Merril CR (1993). "Dinucleotide repeat in the human mitochondrial D-loop.". Hum. Mol. Genet. 1 (2): 140. PMID 1301157. doi:10.1093/hmg/1.2.140-a. 
  • Lin FH, Lin R, Wisniewski HM, et al. (1992). "Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in Alzheimer's brains.". Biochem. Biophys. Res. Commun. 182 (1): 238–46. PMID 1370613. doi:10.1016/S0006-291X(05)80136-6. 
  • Lu X, Walker T, MacManus JP, Seligy VL (1992). "Differentiation of HT-29 human colonic adenocarcinoma cells correlates with increased expression of mitochondrial RNA: effects of trehalose on cell growth and maturation.". Cancer Res. 52 (13): 3718–25. PMID 1377597. 
  • Brown MD, Voljavec AS, Lott MT, et al. (1992). "Mitochondrial DNA complex I and III mutations associated with Leber's hereditary optic neuropathy.". Genetics 130 (1): 163–73. PMC 1204789. PMID 1732158. 
  • Marzuki S, Noer AS, Lertrit P, et al. (1992). "Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.". Hum. Genet. 88 (2): 139–45. PMID 1757091. doi:10.1007/bf00206061. 
  • Johns DR, Berman J (1991). "Alternative, simultaneous complex I mitochondrial DNA mutations in Leber's hereditary optic neuropathy.". Biochem. Biophys. Res. Commun. 174 (3): 1324–30. PMID 1900003. doi:10.1016/0006-291X(91)91567-V. 
  • Moraes CT, Andreetta F, Bonilla E, et al. (1991). "Replication-competent human mitochondrial DNA lacking the heavy-strand promoter region.". Mol. Cell. Biol. 11 (3): 1631–7. PMC 369459. PMID 1996112. 
  • Attardi G, Chomyn A, Doolittle RF, et al. (1987). "Seven unidentified reading frames of human mitochondrial DNA encode subunits of the respiratory chain NADH dehydrogenase.". Cold Spring Harb. Symp. Quant. Biol. 51 Pt 1: 103–14. PMID 3472707. doi:10.1101/sqb.1986.051.01.013. 
  • Chomyn A, Cleeter MW, Ragan CI, et al. (1986). "URF6, last unidentified reading frame of human mtDNA, codes for an NADH dehydrogenase subunit.". Science 234 (4776): 614–8. PMID 3764430. doi:10.1126/science.3764430. 
  • Chomyn A, Mariottini P, Cleeter MW, et al. (1985). "Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.". Nature 314 (6012): 592–7. PMID 3921850. doi:10.1038/314592a0. 
  • Sanger F, Coulson AR, Barrell BG, et al. (1981). "Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing.". J. Mol. Biol. 143 (2): 161–78. PMID 6260957. doi:10.1016/0022-2836(80)90196-5. 
  • Anderson S, Bankier AT, Barrell BG, et al. (1981). "Sequence and organization of the human mitochondrial genome.". Nature 290 (5806): 457–65. PMID 7219534. doi:10.1038/290457a0. 
  • Montoya J, Ojala D, Attardi G (1981). "Distinctive features of the 5'-terminal sequences of the human mitochondrial mRNAs.". Nature 290 (5806): 465–70. PMID 7219535. doi:10.1038/290465a0. 
  • Horai S, Hayasaka K, Kondo R, et al. (1995). "Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.". Proc. Natl. Acad. Sci. U.S.A. 92 (2): 532–6. PMC 42775. PMID 7530363. doi:10.1073/pnas.92.2.532. 
  • Rieder MJ, Taylor SL, Tobe VO, Nickerson DA (1998). "Automating the identification of DNA variations using quality-based fluorescence re-sequencing: analysis of the human mitochondrial genome.". Nucleic Acids Res. 26 (4): 967–73. PMC 147367. PMID 9461455. doi:10.1093/nar/26.4.967. 
  • Wise CA, Sraml M, Easteal S (1998). "Departure from neutrality at the mitochondrial NADH dehydrogenase subunit 2 gene in humans, but not in chimpanzees.". Genetics 148 (1): 409–21. PMC 1459762. PMID 9475751. 
  • Andrews RM, Kubacka I, Chinnery PF, et al. (1999). "Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA.". Nat. Genet. 23 (2): 147. PMID 10508508. doi:10.1038/13779. 
  • Ingman M, Kaessmann H, Pääbo S, Gyllensten U (2001). "Mitochondrial genome variation and the origin of modern humans.". Nature 408 (6813): 708–13. PMID 11130070. doi:10.1038/35047064. 
  • Finnilä S, Lehtonen MS, Majamaa K (2001). "Phylogenetic network for European mtDNA.". Am. J. Hum. Genet. 68 (6): 1475–84. PMC 1226134. PMID 11349229. doi:10.1086/320591. 

External links

  • GeneReviews/NCBI/NIH/UW entry on Mitochondrial DNA-Associated Leigh Syndrome and NARP