Furazolidone

Furazolidone

Furazolidone
Structural formula of furazolidone
Space-filling model of the furazolidone model
Systematic (IUPAC) name
3-{[(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one
Clinical data
AHFS/Drugs.com
Routes of
administration
Oral-Local
Identifiers
CAS Registry Number  Y
ATC code G01 QJ01
PubChem CID:
DrugBank  Y
ChemSpider  Y
UNII  Y
KEGG  N
ChEMBL  N
Chemical data
Formula C8H7N3O5
Molecular mass 225.16
 N   

Furazolidone is a nitrofuran antibacterial. It is marketed by Roberts Laboratories under the brand name Furoxone and by GlaxoSmithKline as Dependal-M. Diafuron, medaron

Contents

  • Uses 1
    • Use in humans 1.1
    • Use in animals 1.2
    • Use in laboratory 1.3
  • Mechanism 2
  • Side effects 3
  • See also 4
  • References 5

Uses

Furazolidone has been used in human and veterinary medicine. It has a broad spectrum of activity being active against

Use in humans

In humans it has been used to treat diarrhoea and enteritis caused by bacteria or protozoan infections. It has been used to treat traveler's diarrhoea, cholera and bacteremic salmonellosis. Use in treating Helicobacter pylori infections has also been proposed.[1]

Furazolidone is also used for giardiasis (due to Giardia lamblia), though it is not a first line treatment.[2]

Use in animals

As a veterinary medicine, furazolidone has been used with some success to treat salmonids for Myxobolus cerebralis infections.

It has also been used in aquaculture.[3]

Since furazolidone is a nitrofuran antibiotic, its use in food animals is currently prohibited by the FDA under the Animal Medicinal Drug Use Clarification Act, 1994.[4]

Use in laboratory

It is used to differentiate micrococci and staphylococci.

Mechanism

It is believed to work by crosslinking of DNA.[5]

Side effects

Furazolidone is no longer available in the US. Though an effective antibiotic when all others fail, against extremely drug resistant infections, it has many side effects, and as with other nitrofurans generally, minimum inhibitory concentrations also produce systemic toxicity (tremors, convulsions, peripheral neuritis, gastrointestinal disturbances, depression of spermatogenesis.) Nitrofurans are recognized by FDA as mutagens/carcinogens, and can no longer be used since 1991.[6]

See also

References

  1. ^ Machado RS, Silva MR, Viriato A (2008). "Furazolidone, tetracycline and omeprazole: a low-cost alternative for Helicobacter pylori eradication in children". Jornal de pediatria 84 (2): 160–5.  
  2. ^ Petri WA (February 2005). "Treatment of Giardiasis". Curr Treat Options Gastroenterol 8 (1): 13–17.  
  3. ^ Meng J, Mangat SS, Grudzinski IP, Law FC (1998). "Evidence of 14C-furazolidone metabolite binding to the hepatic DNA of trout". Drug Metabol Drug Interact 14 (4): 209–19.  
  4. ^ Bagley, Clell. "Drugs Prohibited from Extralabel Use in Animals". Retrieved 14 April 2014. 
  5. ^ "DrugBank: Showing Furazolidone (DB00614)". Retrieved 2008-12-19. 
  6. ^ http://caraga.da.gov.ph/services/banmed-Nitrofurans.htm