Ernst Boris Chain

Ernst Boris Chain

Sir Ernst Boris Chain
Ernst Boris Chain (1945)
Born (1906-06-19)19 June 1906
Berlin, Germany
Died 12 August 1979(1979-08-12) (aged 73)
Castlebar, Ireland
Residence Berlin (until 1933)
London (from 1933)
Citizenship German (until 1933)
British (from 1933)
Fields Biochemistry
Institutions Imperial College London
University of Cambridge
University of Oxford
Istituto Superiore di Sanità
Alma mater Friedrich Wilhelm University
Known for The development of Penicillin
Notable awards Nobel Prize in Physiology or Medicine (1945)
Fellow of the Royal Society (1948)
Spouse Anne Chain (m. 1948–1979, his death)

Sir Ernst Boris Chain, FRS[1] (19 June 1906 – 12 August 1979) was a German-born British biochemist, and a 1945 co-recipient of the Nobel Prize for Physiology or Medicine for his work on penicillin.[2][3][4][5][6][7][8][9][10][11]


  • Life and career 1
  • See also 2
  • References 3
  • Bibliography 4
  • External links 5

Life and career

Dr Ernest Chain undertakes an experiment in his office at the School of Pathology at Oxford University in 1944
Ernst Chain in his laboratory.

Chain was born in Berlin, the son of Margarete (née Eisner) and Michael Chain, who was a chemist and industrialist dealing in chemical products.[12][13] His family was Jewish. His father emigrated from Russia to study chemistry abroad and his mother was from Berlin.[14] In 1930, he received his degree in chemistry from Friedrich Wilhelm University.

After the Nazis came to power, Chain understood that, being Jewish, he would no longer be safe in Germany. He left Germany and moved to England, arriving on 2 April 1933 with £10 in his pocket. Geneticist and physiologist J.B.S. Haldane helped him obtain a position at University College Hospital, London.

After a couple of months he was accepted as a PhD student at Fitzwilliam House, Cambridge University, where he began working on phospholipids under the direction of Sir Frederick Gowland Hopkins. In 1935, he accepted a job at Oxford University as a lecturer in pathology. During this time he worked on a range of research topics, including snake venoms, tumour metabolism, lysozymes, and biochemistry techniques.

In 1939, he joined Alexander Fleming, who had described penicillin nine years earlier. Chain and Florey went on to discover penicillin's therapeutic action and its chemical composition. He also theorised the structure of penicillin, which was confirmed by X-ray crystallography done by Dorothy Hodgkin. For this research, Chain, Florey, and Fleming received the Nobel Prize in 1945.

Towards the end of World War II, Chain learned his mother and sister had perished in the war. After World War II, Chain moved to Rome, to work at the Istituto Superiore di Sanità (Superior Institute of Health). He returned to Britain in 1964 as the founder and head of the biochemistry department at Imperial College London, where he stayed until his retirement, specialising in fermentation technologies.[15] He was knighted soon after in 1969.[16]

He was a lifelong friend of Professor Albert Neuberger, whom he met in Berlin in the 1930s.

On 17 March 1948 Chain was appointed a fellow by the Royal Society.

In 1948, he married Anne Chain, sister of Max Beloff and Nora Beloff. In his later life, his Jewish identity became increasingly important to him. He became a member of the board of governors of the Weizmann Institute of Science at Rehovot in 1954, and later a member of the executive council. He raised his children securely within the Jewish faith, arranging much extracurricular tuition for them. His views were expressed most clearly in his speech 'Why I am a Jew' given at the World Jewish Congress Conference of Intellectuals in 1965.[2]

Chain died at the Mayo General Hospital in 1979. The Imperial College London biochemistry building is named after him,[15] as is a road in Castlebar.[17]

See also


  1. ^  
  2. ^ a b E. P. Abraham (2004). "‘Chain, Sir Ernst Boris (1906–1979)". The  
  3. ^ Shampo, M. A.; Kyle, R. A. (2000). "Ernst Chain--Nobel Prize for work on penicillin". Mayo Clinic proceedings. Mayo Clinic 75 (9): 882.  
  4. ^ Raju, T. N. (1999). "The Nobel chronicles. 1945: Sir Alexander Fleming (1881-1955); Sir Ernst Boris Chain (1906-79); and Baron Howard Walter Florey (1898-1968)". Lancet 353 (9156): 936.  
  5. ^ Notter, A. (1991). "The difficulties of industrializing penicillin (1928-1942) (Alexander Fleming, Howard Florey, Ernst Boris Chain)". Histoire des sciences medicales 25 (1): 31–38.  
  6. ^ Abraham, E. P. (1980). "Ernst Chain and Paul Garrod". The Journal of antimicrobial chemotherapy 6 (4): 423–424.  
  7. ^ Mansford, K. R. (1979). "Sir Ernst Chain, 1906-1979". Nature 281 (5733): 715–717.  
  8. ^ Abraham, E. P. (1979). "Obituary: Sir Ernst Boris Chain". The Journal of antibiotics 32 (10): 1080–1081.  
  9. ^ "Sir Ernst Chain". British medical journal 2 (6188): 505. 1979.  
  10. ^ "Ernst Boris Chain". Lancet 2 (8139): 427. 1979.  
  11. ^ Wagner, W. H. (1979). "In memoriam, Dr. Ernst Boris Chain". Arzneimittel-Forschung 29 (10): 1645–1646.  
  12. ^ "Ernst B. Chain". 2013. Retrieved 17 July 2013. 
  13. ^ Forder, Arderne A. (1984). The more ye mow us down the more we grow: antibiotics in perspective. University of Cape Town. 
  14. ^ "Chain, Sir Ernst Boris (1906–1979) German/English Biochemist (Scientist)". 2013. Retrieved 17 July 2013. 
  15. ^ a b Martineau, Natasha (5 November 2012). "Sir Ernst Chain is honoured in building naming ceremony".  
  16. ^ "Ernst Boris Chain". 2009. Retrieved 17 July 2013. 
  17. ^


  • Medawar, Jean: Pyke, David (2012). Hitler's Gift: The True Story of the Scientists Expelled by the Nazi Regime (Paperback). New York: Arcade Publishing.  

External links

  • "Ernst B. Chain – Biographical". 
  • Weintraub, B. (August 2003). "Ernst Boris Chain (1906–1979) and Penicillin". Chemistry in Israel (Israel Chemical Society) (13): 29–32.