Dihydrotachysterol

Dihydrotachysterol

Dihydrotachysterol
Systematic (IUPAC) name
(1S,3E,4S)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5,6-Dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylcyclohexan-1-ol
Clinical data
AHFS/Drugs.com
MedlinePlus
Identifiers
CAS Registry Number  Y
ATC code A11
PubChem CID:
DrugBank  Y
ChemSpider  Y
UNII  Y
KEGG  Y
ChEBI  Y
Chemical data
Formula C28H46O
Molecular mass 398.664 g/mol
 Y   

Dihydrotachysterol (DHT) is a synthetic vitamin D analog activated in the liver that does not require renal hydroxylation like vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). DHT has a rapid onset of action (2 hours), a shorter half-life, and a greater effect on mineralization of bone salts than does vitamin D.[1]

References

  1. ^ R. Gagnon, G. W. Ogden, G. Just, M. Kaye (1974). "Comparison of Dihydrotachysterol and 5,6-trans Vitamin D3 on Intestinal Calcium Absorption in Patients with Chronic Renal Failure". Canadian Journal of Physiology and Pharmacology 52 (2): 272–274.