Avram Hershko

Avram Hershko

Avram Hershko
Born Herskó Ferenc
(1937-12-31) 31 December 1937
Karcag, Hungary
Nationality Israel
Fields Chemistry
Known for ubiquitin-mediated protein degradation
Notable awards Nobel Prize in Chemistry (2004)
Spouse Judith Leibowitz (m. 1963)
Children 3

Avram Hershko (Hebrew: אברהם הרשקו‎; born 31 December 1937) is a Hungarian-born Israeli biochemist and Nobel laureate in Chemistry.

Contents

  • Biography 1
  • Honours and awards 2
  • Publications 3
  • Involvement with biotechnology 4
  • See also 5
  • References 6
  • External links 7

Biography

Hershko was born Herskó Ferenc in Karcag, Hungary, the son of Shoshana Margit and Moshe Hershko, both teachers.[1] Hershko emigrated to Israel in 1950. He received his M.D. in 1965 and his Ph.D in 1969 from the Hebrew University-Hadassah Medical School, Jerusalem, Israel. He is currently a Distinguished Professor at the Rappaport Faculty of Medicine at the Technion in Haifa.

Along with Aaron Ciechanover and Irwin Rose, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation. The ubiquitin-proteasome pathway has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of diseases such as cancer, muscular and neurological diseases, and immune and inflammatory responses.

His contributions to science directly helped cure one of his long-time friends of cancer. [2]

Honours and awards

Publications

  • Hershko, A., Ciechanover, A., Heller, H., Haas, A.L., and Rose I.A. (1980) "Proposed role of ATP in protein breakdown: Conjugation of proteins with multiple chains of the polypeptide of ATP-dependent proteolysis". Proc. Natl. Acad. Sci. USA 77, 1783–1786.
  • Hershko, A., Heller, H., Elias, S. and Ciechanover, A. (1983) Components of ubiquitin-protein ligase system: resolution, affinity purification and role in protein breakdown. J. Biol. Chem. 258, 8206–8214.
  • Hershko, A., Leshinsky, E., Ganoth, D. and Heller, H. (1984) ATP-dependent degradation of ubiquitin-protein conjugates. Proc. Natl. Acad. Sci. USA 81, 1619–1623.
  • Hershko, A., Heller, H., Eytan, E. and Reiss, Y. (1986) The protein substrate binding site of the ubiquitin-protein ligase system. J. Biol. Chem. 261, 11992-11999.
  • Ganoth, D., Leshinsky, E., Eytan, E., and Hershko, A. (1988) A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of components and evidence for ATP-dependent complex formation. J. Biol. Chem. 263, 12412-1241.
  • Sudakin, V., Ganoth, D., Dahan, A., Heller, H., Hershko, J., Luca, F.C., Ruderman, J.V. and Hershko, A. (1995). The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell 6, 185–198.

Involvement with biotechnology

Professor Hershko serves on the Scientific Advisory Board of Oramed Pharmaceuticals.

See also

References

  1. ^ http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2004/hershko-autobio.html
  2. ^
  3. ^
  4. ^ Wolf Prize Recipients in Medicine
  5. ^ Nobel citation
  6. ^ Avram Hershko & Aaron Ciechanover, 2004 Nobel in Chemistry – A web article

External links

  • Nobel Prize lecture
  • Website at the Technion
  • Avram Hershko's short talk: "Lessons from My Life in Science"
  • "Hungarian" Nobel Prize winners Crooked Timber
  • Avram Hershko Jewish Virtual Library
  • Ubiquitin-Mediated Protein Degradation: From the lab to the bedside Dan Hersko
  • The Official Site of Louisa Gross Horwitz Prize