Anileridine

Anileridine

Anileridine
Systematic (IUPAC) name
Ethyl 1-[2-(4-aminophenyl)ethyl]-4-phenylpiperidine-4-carboxylate
Clinical data
AHFS/Drugs.com
Legal status
Routes of
administration
Tablets, injection
Pharmacokinetic data
Protein binding > 95%
Metabolism Hepatic
Identifiers
CAS Registry Number  Y
ATC code N01
PubChem CID:
IUPHAR/BPS
DrugBank  Y
ChemSpider  Y
UNII  Y
KEGG  Y
ChEBI  Y
ChEMBL  N
Chemical data
Formula C22H28N2O2
Molecular mass 352.47 g/mol
Physical data
Melting point 83 °C (181 °F)
 N   

Anileridine (trade name: Leritine) is a synthetic analgesic drug and is a member of the piperidine class of analgesic agents developed by Merck & Co. in the 1950s.[1] It differs from pethidine (meperidine) in that the N-methyl group of meperidine is replaced by an N-aminophenethyl group, which increases its analgesic activity.

Anileridine is no longer manufactured in the US or Canada.[2]

Administration

As tablets or injection.[3]

Pharmacokinetics

Anileridine usually takes effect within 15 minutes of either oral or intravenous administration, and lasts 2–3 hours.[4] It is mostly metabolized by the liver.

References

  1. ^ U.S. Patent 2,897,204
  2. ^ "Discontinued Prescription Drug Products". Canadian Pharmacists' Association. Retrieved 28 July 2008. 
  3. ^ "Pharmaceutical Information - LERITINE". RxMed. Retrieved 16 June 2010. 
  4. ^ "Anileridine Consumer Information". MedicineNet. Retrieved 28 July 2008.