- Structure and properties 1
- Biological role 2
- Examples of amphiphiles 3
- References 4
- External links 5
- See also 6
Structure and properties
- Charged groups
- Polar, uncharged groups. Examples are alcohols with large R groups, such as diacyl glycerol (DAG), and oligoethyleneglycols with long alkyl chains.
When placed in an immiscible biphasic system consisting of aqueous and organic solvents, the amphiphilic compound will partition the two phases. The extent of the hydrophobic and hydrophilic portions determines the extent of partitioning.
Phospholipids, a class of amphiphilic molecules, are the main components of biological membranes. The amphiphilic nature of these molecules defines the way in which they form membranes. They arrange themselves into bilayers, by positioning their polar groups towards the surrounding aqueous medium, and their lipophilic chains towards the inside of the bilayer, defining a non-polar region between two polar ones.Biology Online
Although phospholipids are principal constituents of biological membranes, there are other constituents, such as cholesterol and glycolipids, which are also included in these structures and give them different physical and biological properties.
Many other amphiphilic compounds, such as pepducins, strongly interact with biological membranes by insertion of the hydrophobic part into the lipid membrane, while exposing the hydrophilic part to the aqueous medium, altering their physical behavior and sometimes disrupting them.
Examples of amphiphiles
There are several examples of molecules that present amphiphilic properties:
Hydrocarbon based surfactants are an example group of amphiphilic compounds. Their polar region can be either ionic, or non-ionic. Some typical members of this group are: sodium dodecyl sulfate (anionic), Benzalkonium chloride (cationic), Cocamidopropyl betaine (zwitterionic) and 1-octanol (long chain alcohol, non-ionic).
- Structure of a Membrane - The Lipid Chronicles
- Estimating intestinal permeability by surface activity profiling
- Hydrophile, hydrophilic
- Free surface energy
- Sodium dodecyl sulfate
- Amphipathic lipids
- Polymorphism (biophysics)
- Bubbles in Abiogenesis