Alpha amylase inhibitor

Alpha amylase inhibitor

crystal structure determination, refinement and the molecular model of the alpha-amylase inhibitor hoe-467a
Symbol A_amylase_inhib
Pfam PF01356
InterPro IPR000833
SCOP 1hoe

In molecular biology, alpha-amylase inhibitor is a protein family which inhibits mammalian alpha-amylases specifically, by forming a tight stoichiometric 1:1 complex with alpha-amylase. This family of inhibitors has no action on plant and microbial alpha amylases.

A crystal structure has been determined for tendamistat, the 74-amino acid inhibitor produced by Streptomyces tendae that targets a wide range of mammalian alpha-amylases.[1] The binding of tendamistat to alpha-amylase leads to the steric blockage of the active site of the enzyme. The crystal structure of tendamistat revealed an immunoglobulin-like fold that could potentially adopt multiple conformations. Such molecular flexibility could enable an induced-fit type of binding that would both optimise binding and allow broad target specificity.


  1. ^ König V, Vértesy L, Schneider TR (October 2003). "Structure of the alpha-amylase inhibitor tendamistat at 0.93 A". Acta Crystallogr. D Biol. Crystallogr. 59 (Pt 10): 1737–43.  

This article incorporates text from the public domain Pfam and InterPro IPR000833