24 August 1899|
Longlier, Neufchâteau, Belgium
22 May 1983
|Citizenship||Belgium and Naturalised American|
Institut Jules Bordet
Université Libre de Bruxelles
Université catholique de Louvain
|Alma mater||University of Liège|
Electron microscopy in biology
Louisa Gross Horwitz Prize in 1970
Paul Ehrlich and Ludwig Darmstaedter Prize in 1971
Nobel Prize in Physiology or Medicine in 1974
Albert Claude (24 August 1899 – 22 May 1983) was a mitochondrion, chloroplast, endoplasmic reticulum, Golgi apparatus, ribosome and lysosome. He was the first to employ electron microscope in the field of biology. In 1945 he published the first detailed structure of cell. His collective works established the complex functional and structural properties of cells.
Claude served as Director at Christian de Duve.
- Early life and education 1
- Career 2
- Personal life 3
- Awards and recognitions 4
- References 5
- Further reading 6
- External links 7
Early life and education
Albert Claude was born in 1899 (but according to civil register 1898) in Longlier, a hamlet in Neufchâteau, Belgium, to Florentin Joseph Claude and Marie-Glaudice Watriquant Claude. He was the youngest among three brothers and one sister. His father was a Paris-trained baker and run a bakery-cum-general store at Longlier valley near railroad station. His mother, who developed breast cancer in 1902, died when he was seven years old. He spent his pre-school life with his ailing mother. He started education in Longlier Primary School, a pluralistic school of single room, mixed grades, and all under one teacher. In spite of the inconveniences, he remarked the education system as "excellent." He served as a bell boy, ringing church bell every morning at 6. Due to economic depression the family moved to Athus, a prosperous region with steel mills, in 1907. He entered German-speaking school. After two years he was asked to look after his uncle who was disabled with cerebral haemorrhage in Longlier. He dropped out of school and practically nursed his uncle for several years. At the outbreak of the First World War he was apprenticed to steel mills and worked as an industrial designer. Inspired by Winston Churchill, then British Minister of War, he joined the resistance and volunteered in British Intelligence Service in which he served during the whole war. At the end of the war he was decorated with the Interallied Medal along with veteran status. He then wanted to continue education. Since he had no formal secondary education, particularly required for medicine course, such as in Greek and Latin, he tried to join School of Mining in Liège. By that time Marcel Florkin became head of the Direction of Higher Education in Belgium’s Ministry of Public Instruction, and under his administration passed the law that enabled war veterans to pursue higher education without diploma or other examinations. As an honour to his war service, he was given admission to the University of Liège in 1922 to study medicine. He obtained his degree of Doctor of Medicine in 1928.
Claude received travel grants from Belgian government for his doctoral thesis on the transplantation of mouse cancers into rats. With this he worked his postdoctoral research in Berlin during the winter of 1928-1929, first at the Institut für Krebsforschung, and then at the Kaiser Wilhelm Institute for Biology, Dahlem, in the laboratory of tissues culture of Prof. Albert Fischer. Back in Belgium he received fellowship in 1929 from the Belgian American Educational Foundation (Commission for Relief in Belgium, CRB) for research in the United States. He applied for the Rockefeller Institute (now the Rockefeller University) in New York, USA. Simon Flexner, then Director, accepted his proposal to work on the isolation and identification of the Rous sarcoma virus. In September 1929 he joined the Rockefeller Institute. In 1930, he discovered the process of cell fractionation, which was groundbreaking in his time. The process consists of grinding up cells to break the membrane and release the cell's contents. He then filtered out the cell membranes and placed the remaining cell contents in a centrifuge to separate them according to mass. He divided the centrifuged contents into fractions, each of a specific mass, and discovered that particular fractions were responsible for particular cell functions. In 1938 he identified and purified for the first time component of Rous sarcoma virus, the causal agent of carcinoma, as "ribose nucleoprotein" (eventually named RNA). He was the first to use electron microscope to study biological cells. Earlier electron microscopes were used only in physical researches. His first electron microscopic study was on the structure of mitochondria in 1945. He was given American citizenship in 1941. He discovered that mitochondria are the "power houses" of all cells. He also discovered cytoplasmic granules full of RNA and named them "microsomes", which were later renamed ribosomes, the protein synthesizing machineries of cell. With his associate, Keith Porter, he found a "lace-work" structure that was eventually proven to be the major structural feature of the interior of all eukaryotic cells. This was the discovery of endoplasmic reticulum (a Latin for "fishnet").
In 1949, he became Director of the Jules Bordet Institute for Cancer Research and Treatment (Institut Jules Bordet) and Professor at the Faculty of Medicine of the University of Brussels (Université Libre de Bruxelles), where he was Emeritus in 1971.
In the mid sixties during an Electron Microscopy symposium in (Bratislava)-(Czechoslovakia) oganized by the (UNESCO) at the Czechoslovak Academy of Sciences, he meets young scientist Dr. Emil Mrena who was at that time head of the Elecron Microscopy department. He invited him to come and work with him in Brussels, making it possible for Dr. Mrena's family to escape the communist regime. Their close collaboration gave fruition to 5 publications from 1969 to 1974. With the support of his colleague and friend Christian de Duve, he became in 1972 Professor at the Catholic University of Louvain (Université catholique de Louvain) and Director of the "Laboratoire de Biologie Cellulaire et Cancérologie" in Louvain-la-Neuve where he moved with Dr. Emil Mrena as sole collaborator. At the same time he was appointed Professor at the Rockefeller University, an institution with which he had remained connected, in different degrees, since 1929.
After his retirement in 1971 from the University of Brussels and from the directorship of the Institut Jules Bordet, he continued his research at the Catholic University of Louvain with his collaborator Dr. Emil Mrena, who ended up resigning in 1977 due to decreasing activity of the Laboratory, moving to other research works. It is said that he continued his research in seclusion until he died of natural causes, at his home in Brussels, on Sunday night on 22 May 1983, but he had stopped visiting his own laboratory in Louvain already in 1976 due to his weak health.
Awards and recognitions
- Baron Holvoet Prize of the Fonds National de la Recherche Scientifique of Belgium in 1965
- Louisa Gross Horwitz Prize in 1970 from Columbia University
- Paul Ehrlich and Ludwig Darmstaedter Prize in 1971
- Medal of the Belgian Academy of Medicine
- Member of the Royal Academies for Science and the Arts of Belgium
- Member of the French Academy of Sciences
- Honorary member of the American Academy of Arts and Sciences
- Order of the Palmes Académiques of France
- Grand Cordon of the Order of Léopold II
- Honorary doctorates from the universities of Modena, Brno, Liège, Louvain, Gent, and the Rockefeller University.
- Claude, Albert. "Albert Claude - Biographical". www.nobelprize.org. Nobel Media AB. Retrieved 4 February 2014.
- Altman, Lawrence K. (24 May 1984). "DR. ALBERT CLAUDE DEAD AT 84; WON NOBEL PRIZE IN MEDICINE". The New York Times. Retrieved 4 February 2014.
- "Albert Claude Biography (1898-1983)". Advameg, Inc. Retrieved 5 February 2014.
- "Claude, Albert.". Complete Dictionary of Scientific Biography. The Encyclopedia.com. Retrieved 5 February 2014.
- Palade GE (1971). "Albert Claude and the beginnings of biological electron microscopy". The Journal of Cell Biology 50 (1): 5d–19d.
- Raju TN (1999). "The Nobel chronicles. 1974: Albert Claude (1899-1983), George Emil Palade (b 1912), and Christian Réne de Duve (b 1917)". The Lancet 345 (9185): 1219.
- Gompel C (2006). "Albert Claude, an exceptional man". Bull Mem Acad R Med Belg 161 (10-12): 543–55.
- Aitchison, J. D. (12 May 2003). "Inventories to insights". The Journal of Cell Biology 161 (3): 465–469.
- Rheinberger, H J (1997). "Cytoplasmic particles in Brussels (Jean Brachet, Hubert Chantrenne, Raymond Jeener) and at Rockefeller (Albert Claude), 1935-1955". History and philosophy of the life sciences 19 (1): 47–67.
- Frühling, J (August 1994). "[Eulogy of Professor Albert Claude, Nobel Prize in Medicine and Physiology in 1974]". Bull. Mem. Acad. R. Med. Belg. 149 (12): 466–9.
- Brachet, J (1988). "[Notice sur Albert Claude, Associé de l'Académie]" (PDF). Annuaire de l'Académie royale de Belgique: 93–135.
- de Duve, C (1987). "[Albert Claude and the beginnings of modern cell biology]". La Cellule 74: 11–9.
- Henry, J (1984). "[Eulogy to Professor Albert Claude, honorary member of the Royal Academy]". Bull. Mem. Acad. R. Med. Belg. 139 (3): 197–202.
- de Duve, C; Palade G E (1983). "Albert Claude, 1899-1983".
- Tagnon, H (June 1983). "[In memoriam Prof. Albert Claude]". Revue médicale de Bruxelles 4 (6): 450–2.
- Olsen, B R; Lie S O (December 1974). "[Nobel prize in medicine 1974 (Albert Claude, George Palade, Christian de Duve)]". Tidsskr. Nor. Laegeforen. 94 (34–36): 2400–3.
- Florkin, M (October 1972). "[A salute to Albert Claude]". Arch. Int. Physiol. Biochim. 80 (4): 632–47.
- Florkin, M (December 1974). "[Homage to Albert Claude and Christian de Duve, Nobel Prize laureates in medicine and physiology, 1974]". Arch. Int. Physiol. Biochim. 82 (5): 807–15.
- Palade, G E (July 1971). "Albert Claude and the beginnings of biological electron microscopy". J. Cell Biol. 50 (1): 5d–19d.
- His list of publications on the Institutional Repository of Université libre de Bruxelles
- Nobel Prize Autobiography
- The Official Site of Louisa Gross Horwitz Prize
- Biography at biography.com
- Science Quotes by Albert Claude
- Profile at Rockefeller University