Adenine nucleotide translocator
|solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4|
|Alt. symbols||PEO3, PEO2, ANT1|
|Locus||Chr. 4 q35|
|solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5|
|Locus||Chr. X q24-q26|
|solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6|
|Locus||Chr. Y p|
Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocator, exports ATP from the mitochondrial matrix and imports ADP into the matrix. ANT is the most plentiful protein in the inner mitochondrial membrane.
- Function 1
- Types 2
- See also 3
- Footnotes 4
- External links 5
ANT has long been thought to function asymmetrically as a homodimer of subunits in the inner mitochondrial membrane. The dimer was thought to be a gated pore through which ADP and ATP were exchanged between the mitochondrial matrix and the cytoplasm. The dimer hypothesis was first challenged when the three-dimensional structure of ANT was discovered to be a monomer. Further work has shown that ANT functions a monomer in detergents and in mitochondrial membranes.
- SLC25A4 – found primarily in heart and skeletal muscle
- SLC25A5 – primarily expressed in fibroblasts
- SLC25A6 – primarily express in liver
- Kaukonen J, Juselius JK, Tiranti V, Kyttälä A, Zeviani M, Comi GP, Keränen S, Peltonen L, Suomalainen A (2000). "Role of adenine nucleotide translocator 1 in mtDNA maintenance".
- Pebay-Peyroula E, Dahout-Gonzalez C, Kahn R, Trézéguet V, Lauquin GJ, Brandolin G (November 2003). "Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside". Nature 426 (6962): 39–44.
- Bamber L, Slotboom DJ, Kunji ER (August 2007). "Yeast mitochondrial ADP/ATP carriers are monomeric in detergents as demonstrated by differential affinity purification". J. Mol. Biol. 371 (2): 388–95.
- Bamber L, Harding M, Monné M, Slotboom DJ, Kunji ER (June 2007). "The yeast mitochondrial ADP/ATP carrier functions as a monomer in mitochondrial membranes". Proc. Natl. Acad. Sci. U.S.A. 104 (26): 10830–4.
- Kunji ER, Crichton PG (March 2010). "Mitochondrial carriers function as monomers". Biochim Biophys Acta 1797 (6–7): 817–831.
- Adenine Nucleotide Translocator 1 at the US National Library of Medicine Medical Subject Headings (MeSH)
- Adenine Nucleotide Translocator 2 at the US National Library of Medicine Medical Subject Headings (MeSH)
- Adenine Nucleotide Translocator 3 at the US National Library of Medicine Medical Subject Headings (MeSH)