Adenine nucleotide translocator

Adenine nucleotide translocator

solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
Identifiers
Symbol SLC25A4
Alt. symbols PEO3, PEO2, ANT1
Entrez 291
HUGO 10990
OMIM 103220
RefSeq NM_001151
UniProt P12235
Other data
Locus Chr. 4 q35
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
Identifiers
Symbol SLC25A5
Alt. symbols ANT2
Entrez 292
HUGO 10991
OMIM 300150
RefSeq NM_001152
UniProt P05141
Other data
Locus Chr. X q24-q26
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
Identifiers
Symbol SLC25A6
Alt. symbols ANT3
Entrez 293
HUGO 10992
OMIM 403000
RefSeq NM_001636
UniProt P12236
Other data
Locus Chr. Y p

Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocator, exports ATP from the mitochondrial matrix and imports ADP into the matrix.[1] ANT is the most plentiful protein in the inner mitochondrial membrane.[1]

Contents

  • Function 1
  • Types 2
  • See also 3
  • Footnotes 4
  • External links 5

Function

ANT has long been thought to function asymmetrically as a homodimer of subunits in the inner mitochondrial membrane. The dimer was thought to be a gated pore through which ADP and ATP were exchanged between the mitochondrial matrix and the cytoplasm. The dimer hypothesis was first challenged when the three-dimensional structure of ANT was discovered to be a monomer.[2] Further work has shown that ANT functions a monomer in detergents[3] and in mitochondrial membranes.[4][5]

ANT is an important structural component of the mitochondrial permeability transition pore[1] which can open and lead to cell death through apoptosis or necrosis.

Types

In humans, there exist three paraologous ANT isoforms:

  • SLC25A4 – found primarily in heart and skeletal muscle
  • SLC25A5 – primarily expressed in fibroblasts
  • SLC25A6 – primarily express in liver

See also

Footnotes

  1. ^ a b c Kaukonen J, Juselius JK, Tiranti V, Kyttälä A, Zeviani M, Comi GP, Keränen S, Peltonen L, Suomalainen A (2000). "Role of adenine nucleotide translocator 1 in mtDNA maintenance".  
  2. ^ Pebay-Peyroula E, Dahout-Gonzalez C, Kahn R, Trézéguet V, Lauquin GJ, Brandolin G (November 2003). "Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside". Nature 426 (6962): 39–44.  
  3. ^ Bamber L, Slotboom DJ, Kunji ER (August 2007). "Yeast mitochondrial ADP/ATP carriers are monomeric in detergents as demonstrated by differential affinity purification". J. Mol. Biol. 371 (2): 388–95.  
  4. ^ Bamber L, Harding M, Monné M, Slotboom DJ, Kunji ER (June 2007). "The yeast mitochondrial ADP/ATP carrier functions as a monomer in mitochondrial membranes". Proc. Natl. Acad. Sci. U.S.A. 104 (26): 10830–4.  
  5. ^ Kunji ER, Crichton PG (March 2010). "Mitochondrial carriers function as monomers". Biochim Biophys Acta 1797 (6–7): 817–831.  

External links