Aaron Ciechanover

Aaron Ciechanover

Aaron Ciechanover
Born (1947-10-01) October 1, 1947
Haifa, British Mandate of Palestine (now Israel)
Nationality Israeli
Fields Biology
Known for Ubiquitin-mediated protein degradation
Notable awards Nobel Prize in Chemistry (2004)
Spouse Menucha Ciechanover

Aaron Ciechanover ( pronunction   ; אהרן צ'חנובר; born October 1, 1947) is an Israeli biologist, who won the Nobel prize in Chemistry for characterizing the method that cells use to degrade and recycle proteins using ubiquitin.

Contents

  • Biography 1
  • Publications 2
  • Industry involvement 3
  • Awards 4
  • See also 5
  • References 6
  • External links 7

Biography

Ciechanover was born in Haifa, a year before the establishment of Israel. He is the son of Bluma (Lubashevsky), a teacher of English, and Yitzhak Ciechanover, an office worker.[1] His family were Jewish immigrants from Poland before World War II.

He earned a master's degree in science in 1971 and graduated from Hadassah Medical School in Jerusalem in 1974. He received his doctorate in biochemistry in 1981 from the Technion – Israel Institute of Technology in Haifa before conducting postdoctoral research in the laboratory of Harvey Lodish at the Whitehead Institute at MIT from 1981-1984. He is currently a Technion Distinguished Research Professor in the Ruth and Bruce Rappaport Faculty of Medicine and Research Institute at the Technion.

Ciechanover is a member of the Israel Academy of Sciences and Humanities, the Pontifical Academy of Sciences, and is a foreign associate of the United States National Academy of Sciences.

As one of Israel's first Nobel Laureates in Science, he is honored in playing a central role in the history of Israel and in the history of the Technion – Israel Institute of Technology.

Publications

  • Ciechanover, A., Hod, Y. and Hershko, A. (1978). A Heat-stable Polypeptide Component of an ATP-dependent Proteolytic System from Reticulocytes. Biochem. Biophys. Res. Commun. 81, 1100–1105.
  • Ciechanover, A., Heller, H., Elias, S., Haas, A.L. and Hershko, A. (1980). ATP-dependent Conjugation of Reticulocyte Proteins with the Polypeptide Required for Protein Degradation. Proc. Natl. Acad. Sci. USA 77, 1365–1368.
  • Hershko, A. and Ciechanover, A. (1982). Mechanisms of intracellular protein breakdown. Annu. Rev. Biochem. 51, 335–364.

Industry involvement

Ciechanover has served on the Scientific Advisory Boards of the following companies: Rosetta Genomics (Chairman), BioLineRx, Ltd, StemRad, Ltd, Allosterix Ltd, Proteologics, Inc, MultiGene Vascular Systems, Ltd, Protalix BioTherapeutics and BioTheryX, Inc.

Ciechanover is a member of the Advisory Board of Patient Innovation, a nonprofit, international, multilingual, free venue for patients and caregivers of any disease to share their innovations.

Awards

See also

References

  1. ^ http://encyclopedia.jrank.org/articles/pages/5635/Ciechanover-Aaron-1947.html
  2. ^
  3. ^
  4. ^ Nobel citation
  5. ^ Aaron Ciechanover and Avram Hershko 2004 Nobel in Chemistry – A web article
  6. ^

External links

  • Nobel Prize Lecture
  • Website at the Technion
  • [1]
  • A video interview with Aaron Ciechanover