|ADP-ribosyltransferase 4 (Dombrock blood group)|
|Symbols||; ARTC4; CD297; DO; DOK1|
|RNA expression pattern|
Ecto-ADP-ribosyltransferase 4 is an enzyme that in humans is encoded by the ART4 gene. ART4 has also been designated as CD297 (cluster of differentiation 297). This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinositol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known.
Blood group antigens
Several antigens have been recognised in this family. These are DO*A, DO*JO1, DO*A-WL, DO*DOYA, DO*B, DO*B-WL, DO*B-SH-Q149K, DO*B-(WL)-I175N, DO*HY1, DO*HY2 and DO*DOMR.
|Mouse Mutant Alleles for Art4|
|Marker Symbol for Mouse Gene. This symbol is assigned to the genomic locus by the MGI||Art4|
|Mutant Mouse Embryonic Stem Cell Clones. These are the known targeted mutations for this gene in a mouse.||tm1aWTSI(KOMP)Art4|
|Example structure of targeted conditional mutant allele for this gene|
These Mutant ES Cells can be studied directly or used to generate mice with this gene knocked out. Study of these mice can shed light on the function of Art4:
see Knockout mouse
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- "Entrez Gene: ART4 ADP-ribosyltransferase 4 (Dombrock blood group)".
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- Rios M, Storry JR, Hue-Roye K et al. (2002). "Two new molecular bases for the Dombrock null phenotype". Br. J. Haematol. 117 (3): 765–7.
- Glowacki G, Braren R, Firner K et al. (2003). "The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse". Protein Sci. 11 (7): 1657–70.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7.
- Grahnert A, Friedrich M, Engeland K, Hauschildt S (2005). "Analysis of mono-ADP-ribosyltransferase 4 gene expression in human monocytes: splicing pattern and potential regulatory elements". Biochim. Biophys. Acta 1730 (3): 173–86.
- ART4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)